ArticleApplied and environmental microbiology2020
Vib-PT, an Aromatic Prenyltransferase Involved in the Biosynthesis of Vibralactone from
Article in Applied and environmental microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors.Applied microbiology and biotechnology · 2023Article
- A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone.Nature communications · 2023Article
- Identification and Mechanism of Action of the Global Secondary Metabolism Regulator SaraC inMicrobiology spectrum · 2022Article
- Functional Characterization and Screening of Promiscuous Kinases and Isopentenyl Phosphate Kinases for the Synthesis of DMAPP via a One-Pot Enzymatic Cascade.International journal of molecular sciences · 2022Article
- In Depth Natural Product Discovery from the BasidiomycetesMicroorganisms · 2020Review
- A versatile cis-prenyltransferase from Methanosarcina mazei catalyzes both C- and O-prenylations.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibralactone, a hybrid compound derived from phenols and a prenyl group, is a strong pancreatic lipase inhibitor with a rare fused bicyclic β-lactone skeleton. Recently, a researcher reported a vibralactone derivative (compound C1) that caused inhibition of pancreatic lipase with a half-maximal inhibitory concentration of 14 nM determined by structure-based optimization, suggesting a potential candidate as a new antiobesity treatment. In the present study, we sought to identify the main gene encoding prenyltransferase in
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.