ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Disruptive Behavior Problems, Callous-Unemotional Traits, and Regional Gray Matter Volume in the Adolescent Brain and Cognitive Development Study.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Aberrant Resting-State Functional Connectivity Associated With Callous-Unemotional Traits From Late Childhood Through Late Adolescence.Biological psychiatry global open science · 2026Article
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- Emotional and attentional anomalies underlying triarchic psychopathic traits: an EEG-startle blink study.BMC psychology · 2026Article
- Hypothalamus volumes and mental health in children and adolescents.Frontiers in neuroscience · 2026Article
- Alterations in Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits in Adolescents.Brain and behavior · 2025Article
- Callous-unemotional traits, cognitive functioning, and externalizing problems in a propensity-matched sample from the ABCD study.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The amygdala volume moderates the relationship between childhood maltreatment and callous-unemotional traits in adolescents with conduct disorder.European child & adolescent psychiatry · 2025Article
- Evaluating the sensitivity to threat and affiliative reward (STAR) model in relation to the development of conduct problems and callous-unemotional traits across early adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Callousness, exploitativeness, and tracking of cooperation incentives in the human default network.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- White matter microstructure, traumatic brain injury, and disruptive behavior disorders in girls and boys.Frontiers in neuroscience · 2024Article
- Brain Changes Linked to Cognitive Symptomatology in Homeless Youth.Clinical nursing research · 2023Article
- Antisocial behavior is associated with reduced frontoparietal network efficiency in youth.Social cognitive and affective neuroscience · 2023Article
- Effects of multidomain environmental and mental health factors on the development of empathetic behaviors and emotions in adolescence.PloS one · 2023Article
- Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort.Neuroscience applied · 2023Article
- Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample.Development and psychopathology · 2022Article
- Multivariate Genetic Structure of Externalizing Behavior and Structural Brain Development in a Longitudinal Adolescent Twin Sample.International journal of molecular sciences · 2022Article
- Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling.Molecular psychiatry · 2022Article
- Identifying profiles of brain structure and associations with current and future psychopathology in youth.Developmental cognitive neuroscience · 2021Article
- Psychopathy.Nature reviews. Disease primers · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNeurobiological differences linked to socioemotional and cognitive processing are well documented in youths with disruptive behavior disorders (DBDs), especially youths with callous-unemotional (CU) traits. The current study expanded this literature by examining gray matter volume (GMV) differences among youths with DBD with CU traits (DBDCU+), youths with DBD without CU traits (DBD-only), and youths that were typically developing (TD).
methodsData were from the first full sample release of the Adolescent Brain and Cognitive Development Study (mean age = 9.49 years; 49% female). We tested whether the GMVs of 11 regions of interest selected a priori differentiated between our 3 groups: DBDCU+ (n = 288), DBD-only (n = 362), and TD (n = 915). Models accounted for demographic confounders, attention-deficit/hyperactivity disorder, and intracranial volume. We examined two potential moderators of the relationship between GMVs and group membership: sex and clinically significant anxiety (i.e., primary vs. secondary CU traits subtype).
resultsYouths in the DBDCU+ group had lower right amygdala GMV, and youths in the DBD-only group had lower bilateral amygdala GMV relative to TD youths. Youths in the DBDCU+ group had lower bilateral hippocampal GMV, and youths in the DBD-only group had lower left hippocampal GMV relative to TD youths. Youths in the DBDCU+ group evidenced lower left insula GMV relative to TD youths. Finally, youths in the DBD-only group had lower left superior frontal gyrus and lower right caudal anterior cingulate cortex GMVs relative to TD youths. There was no moderation of associations between GMV and group membership by sex.
conclusionsOur findings implicate structural aberrations in both the amygdala and hippocampus in the etiology of DBDs, with minimal evidence for differences based on the presence or absence of CU traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.