ArticleCellular immunology2020
NK cells prevent T cell lymphoma development in T cell receptor-transgenic mice.
Article in Cellular immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Bi-directional support of T lymphoma and a lymphoma-associated monocyte population involving Notch signaling in mice.Oncoimmunology · 2026Article
- High-multiplex single-cell imaging analysis reveals tumor immune contexture associated with clinical outcomes after CAR T cell therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Effective Cytotoxicity of Dendritic Cells against Established T Cell Lymphomas in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Engagement of lymphoma T cell receptors causes accelerated growth and the secretion of an NK cell-inhibitory factor.Cellular immunology · 2020Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Mice that express a single transgenic T cell receptor have a low incidence of T cell lymphoma development. We investigated whether this tumor development is restricted by surveillance mechanisms that are exerted by IL-15-dependent cells. Lymphoma incidence was increased to between 30 and 60% when TCR transgenes were expressed in IL-15-deficient mice. Mice in which NK cells had been depleted genetically or with neutralizing antibodies allowed lymphoma growth while the absence of CD8 T cells was without consequence. Half of the emerged T cell lymphomas carried Notch1 mutations. The distinct phenotype of the lymphomas involved expression of PD1, CD30, CD24, the stress receptor ligand Mult1 and MHC class I down-regulation. NK cells were able to directly lyse lymphoma cells, and neutralizations of Mult1 and class I expression prevented NK cell degranulation. Together these data support an involvement of NK cells in tumor surveillance of nascent T cell lymphomas.
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