Evidence map›Paper›PMID 32143713›Full record

ArticleParasites & vectors2020

Comparison of infectivity of Plasmodium vivax to wild-caught and laboratory-adapted (colonized) Anopheles arabiensis mosquitoes in Ethiopia.

Wakweya Chali, Temesgen Ashine, Elifaged Hailemeskel, Abrham Gashaw, Temesgen Tafesse, Kjerstin Lanke, Endashaw Esayas, Soriya Kedir, Girma Shumie, Sinknesh Wolde Behaksra and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. Infectivity of symptomaticCurrent research in parasitology & vector-borne diseases · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 4 countries.

Wakweya ChaliMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
Temesgen AshineMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
Elifaged HailemeskelMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
Abrham GashawMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
Temesgen TafesseMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
Kjerstin LankeDepartment of Medical Microbiology, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Endashaw EsayasMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
Soriya KedirOromia Regional Laboratory, Oromia Regional Health Bureau, Adama, Ethiopia.
Girma ShumieMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
Sinknesh Wolde BehaksraMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
John BradleyDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, WC1E 7HT, London, UK.
Delenasaw YewhalawTropical and Infectious Diseases Research Center, Jimma University, P.O.Box 5195, Jimma, Ethiopia.
Hassen MamoDepartment of Microbial, Cellular and Molecular Biology, College of Natural and Computational Sciences, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia.
Beyene PetrosDepartment of Microbial, Cellular and Molecular Biology, College of Natural and Computational Sciences, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia.
Chris DrakeleyDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, WC1E 7HT, London, UK.
Endalamaw GadisaMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia.
Teun BousemaDepartment of Medical Microbiology, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Fitsum G TadesseMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia. fitsum.girma@ahri.gov.et.ORCID http://orcid.org/0000-0003-1931-1442
Armauer Hansen Research Institute · ETRadboud University Nijmegen · NLAddis Ababa University · ETLondon School of Hygiene & Tropical Medicine · GBJimma University · ETOromiyaa Regional Health Bureau · ET

Funding

Bill and Melinda Gates Foundation INDIE OPP1173572Medical Research Council MR/R010161/1
6 · The paper itself

Abstract

backgroundMosquito-feeding assays that assess transmission of Plasmodium from man-to-mosquito typically use laboratory mosquito colonies. The microbiome and genetic background of local mosquitoes may be different and influence Plasmodium transmission efficiency. In order to interpret transmission studies to the local epidemiology, it is therefore crucial to understand the relationship between infectivity in laboratory-adapted and local mosquitoes.

methodsWe assessed infectivity of Plasmodium vivax-infected patients from Adama, Ethiopia, using laboratory-adapted (colony) and wild-caught (wild) mosquitoes raised from larval collections in paired feeding experiments. Feeding assays used 4-6 day-old female Anopheles arabiensis mosquitoes after starvation for 12 h (colony) and 18 h (wild). Oocyst development was assessed microscopically 7 days post-feeding. Wild mosquitoes were identified morphologically and confirmed by genotyping. Asexual parasites and gametocytes were quantified in donor blood by microscopy.

resultsIn 36 paired experiments (25 P. vivax infections and 11 co-infections with P. falciparum), feeding efficiency was higher in colony (median: 62.5%; interquartile range, IQR: 47.0-79.0%) compared to wild mosquitoes (median: 27.8%; IQR: 17.0-38.0%; Z = 5.02; P < 0.001). Plasmodium vivax from infectious individuals (51.6%, 16/31) infected a median of 55.0% (IQR: 6.7-85.7%; range: 5.5-96.7%; n = 14) of the colony and 52.7% (IQR: 20.0-80.0%; range: 3.2-95.0%; n = 14) of the wild mosquitoes. A strong association (ρ

conclusionsInfectivity assessments with colony and wild mosquitoes yielded similar infection results. This finding supports the use of colony mosquitoes for assessments of the infectious reservoir for malaria in this setting whilst acknowledging the importance of mosquito factors influencing sporogonic development of Plasmodium parasites.

Indexed as

LaboratoriesAnimalsAnophelesEthiopiaFeeding BehaviorFemaleHost-Parasite InteractionsHumansLarvaMalariaMalaria, VivaxMosquito VectorsOocystsPlasmodium vivaxAnopheles arabiensisInfectivityMembrane-feedingPlasmodium vivaxRelative permissivenessWild mosquito

Identifiers

PMID32143713
PMCPMC7059271
OpenAlexW3011166453

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.