ArticleCritical care (London, England)2020
Effect of postextubation high-flow nasal cannula therapy on lung recruitment and overdistension in high-risk patient.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of High-Flow Nasal Cannula Therapy on Lung Recruitment and Lung Strain Change Assessed by Electrical Impedance Tomography
Using Electrical Impedance Tomography to Investigate the Relationship Between Airflow Rate During High-flow Oxygen Therapy and Pressure in Patients With Heart Failure Compared to Non-invasive Ventilation
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Perioperative oxygen therapy in patients undergoing surgical procedures: an overview of systematic reviews and meta-analyses.Health technology assessment (Winchester, England) · 2025Pooled it
- The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review.Critical care (London, England) · 2023Pooled it
- The effect of high-flow nasal cannula oxygen therapy on preventing hypoxemia during deep sedation extubation after laparoscopic surgery: a prospective randomized controlled trial.BMC anesthesiology · 2026Trial
- Performance of an indigenously developed high-flow nasal cannula device in healthy human volunteers.BMC anesthesiology · 2026Trial
- An Analysis of the Effect of Noninvasive Positive Pressure Ventilation on Patients with Respiratory Failure Complicated by Diabetes Mellitus.Disease markers · 2022Trial
- Trial
- Prophylactic Postoperative High Flow Nasal Oxygen Versus Conventional Oxygen Therapy in Obese Patients Undergoing Bariatric Surgery (OXYBAR Study): a Pilot Randomised Controlled Trial.Obesity surgery · 2021Trial
- EIT-guided chest physiotherapy for airway clearance during awake prone ventilation in ARDS: a randomized controlled trial.Journal of thoracic disease · 2025Article
- Digital twins suggest a mechanistic basis for differing responses to increased flow rates during high-flow nasal cannula therapy.Intensive care medicine experimental · 2025Article
- Letter on "Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study".Annals of intensive care · 2024Article
- Comparison of the efficacy and comfort of high-flow nasal cannula with different initial flow settings in patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis.Journal of intensive care · 2023Article
- Volume-OXygenation Index to Predict High-flow Nasal Cannula Failure: How to Capture the Tidal Volume Matters.American journal of respiratory and critical care medicine · 2023Article
- Observational
- Clinical review of high-flow nasal oxygen therapy in human and veterinary patients.Frontiers in veterinary science · 2023Review
- The Utility of High-Flow Nasal Oxygen Therapy in a Patient with Pneumonia Undergoing Lower Limb Orthopaedic Surgery: A Case Report.Turkish journal of anaesthesiology and reanimation · 2022Article
- Perioperative oxygen therapy: a protocol for an overview of systematic reviews and meta-analyses.Systematic reviews · 2022Article
- Perioperative role of high flow nasal oxygen therapy in elderly patients undergoing emergency lower limb amputation.Indian journal of anaesthesia · 2022Article
- Role of daytime variation in pharmaceutical effects of sufentanil, dezocine, and tramadol: A matched observational study.Frontiers in pharmacology · 2022Article
- High Flow Oxygen Therapy at Two Initial Flow Settings versus Conventional Oxygen Therapy in Cardiac Surgery Patients with Postextubation Hypoxemia: A Single-Center, Unblinded, Randomized, Controlled Trial.Journal of clinical medicine · 2021Article
- The use of electrical impedance tomography for individualized ventilation strategy in COVID-19: a case report.BMC pulmonary medicine · 2021Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostextubation high-flow nasal cannula (HFNC) is used as a support therapy in high-risk patients in ICU. This study aimed to determine the effects of HFNC therapy on lung recruitment and overdistension assessed by electrical impedance tomography (EIT).
methodsTwenty-four patients who received HFNC within 24 h after extubation were prospectively enrolled in this study. EIT was used to monitor regional lung ventilation distributions at baseline (conventional oxygen therapy) and three flow rate levels of HFNC therapy (20, 40, and 60 L/min). Change of end-expiratory lung impedance (ΔEELI), regional recruitment (recruited-pixels) and overdistension (overdistended-pixels), and lung strain change were determined by EIT. EIT images were equally divided into four ventral-to-dorsal horizontal regions of interest (ROIs 1, 2, 3, and 4). "Overdistension-
resultsWhen the flow rate gradually increased from baseline to 60 L/min, a significant and consistent increasing trend of global ΔEELI (%) (p < 0.0001), recruited-pixels (p < 0.001), and overdistended-pixels (p = 0.101) was observed. Moreover, the increase of ΔEELI was mainly distributed in ROI2 (p = 0.001) and ROI3 (p < 0.0001). The HPR group (13/24 patients) had significantly higher recruited-pixels than the LPR group (11/24 patients) at 20, 40, and 60 L/min. There were no significant differences in PaO
conclusionsUsing EIT could identify diverse effects of HFNC on lung regional ventilation in postextubation situations. Further study is required to validate using "HFNC effect" based on lung recruitment and overdistension by EIT in clinical practice.
trial registrationThe study was retrospectively registered at www.clinicaltrials.gov (no. NCT04245241).
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.