Evidence map›Paper›PMID 32143663›Full record

ArticleBMC pediatrics2020

Clinical, genetic and microbiological characterization of pediatric patients with cystic fibrosis in a public Hospital in Ecuador.

Yazmina Lascano-Vaca, Esteban Ortiz-Prado, Lenin Gomez-Barreno, Katherine Simbaña-Rivera, Eduardo Vasconez, Alexander Lister, María Emilia Arteaga-Espinosa, Geovanny F Perez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Yazmina Lascano-VacaPediatric Pneumology Service, Pediatric Unit of the Carlos Andrade Marin Specialties Hospital, Quito, Ecuador.
Esteban Ortiz-PradoOne Health Research Group, Universidad de Las Americas, José Queri and Av. de los Granados, Quito, Ecuador. e.ortizprado@gmail.com.ORCID 0000-0002-1895-7498
Lenin Gomez-BarrenoOne Health Research Group, Universidad de Las Americas, José Queri and Av. de los Granados, Quito, Ecuador.
Katherine Simbaña-RiveraOne Health Research Group, Universidad de Las Americas, José Queri and Av. de los Granados, Quito, Ecuador.
Eduardo VasconezOne Health Research Group, Universidad de Las Americas, José Queri and Av. de los Granados, Quito, Ecuador.
Alexander ListerFaculty of Medicine, University of Southampton, Southampton, England.
María Emilia Arteaga-EspinosaGenetics Department, Gynemedic, Mexico City, Mexico.
Geovanny F PerezDivision of Pulmonary and Sleep Medicine, Children's National Health System, Washington, DC, USA.
Universidad de Las Américas · ECChildren's National · USHospital Vozandes · ECUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo carry out a complete clinical, pathological, genetic and microbiological characterization of pediatric patients with molecular confirmed cystic fibrosis (CF) attending the Carlos Andrade Marín Hospital (HCAM) within the study period.

methodsA cross-sectional analysis of the pediatric population with a confirmed diagnosis of CF disease who attended HCAM, one of the largest tertiary-level hospitals in Ecuador, between 2017 and 2018 was performed. All demographic, clinical and genetic variables were obtained from the electronic medical records (EMR) stored by the hospital.

resultsForty seven patients with CF were included in the study. Gender distribution was similar between male (48.9%, n = 23) and female patients (51.1%, n = 24). The Tiffeneau-Pinelli index (FEV

conclusionsTo our best knowledge, this is the first study exploring the clinical, genetic and bacteriological profile of CF's patients in Ecuador. Within the cohort of patients, an important and unique genetic feature was characterized by the presence of the g.204099A > C and the c.206359C > A homozygous polymorphism as well as the presence of the H609R variant, a mutation only reported among Ecuadorians.

Indexed as

Cystic FibrosisChildCross-Sectional StudiesCystic Fibrosis Transmembrane Conductance RegulatorEcuadorFemaleHospitals, PublicHumansMaleMutationCystic Fibrosis Transmembrane Conductance RegulatorClinical characterizationCystic fibrosisEpidemiological analysis

Identifiers

PMID32143663
PMCPMC7060626
OpenAlexW3012211915

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.