Evidence map›Paper›PMID 32143662›Full record

ArticleJournal of orthopaedic surgery and research2020

Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people.

Feimeng An, Litian Zhang, Hongyan Gao, Jiaqi Wang, Chang Liu, Ye Tian, Chao Ma, Jian Zhao, Kunzheng Wang, Jianzhong Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
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  6. Article
  7. Steroid-induced osteonecrosis.Journal of translational autoimmunity · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Feimeng AnInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Litian ZhangInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Hongyan GaoInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Jiaqi WangInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Chang LiuInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Ye TianInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Chao MaInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Jian ZhaoInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Kunzheng WangThe Second Affiliated Hospital of Xi'an Jiaotong University, #157 Xi Wu Road, Xi'an, 710004, Shaanxi Province, China. 2437935260@qq.com.
Jianzhong WangDepartment of Trauma Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010030, Inner Mongolia, China. Wangjianzhong1111@163.com.ORCID http://orcid.org/0000-0003-4239-0994
Second Affiliated Hospital of Inner Mongolia Medical University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

National natural science foundation of China 81660228, No.81260284 and No.81660378
6 · The paper itself

Abstract

backgroundGene polymorphism has an important influence on RETN gene expression level, and the increased level of resistin encoded in RETN will lead to metabolic disorder, especially lipid metabolism. Moreover, steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is closely related to lipid metabolism level, so this study is intended to explore the relationship of RETN polymorphisms with susceptibility to steroid-induced ONFH in the Chinese Han population.

methodsIn this case-control study, eight single-nucleotide polymorphisms (SNPs) of RETN were genotyped by the Agena MassARRAY system in 199 steroid-induced ONFH patients and 200 healthy controls. The relationship between RETN polymorphisms and steroid-induced ONFH risk was assessed using genetic models and haplotype analyses. Odds ratio (OR) and 95% confidence intervals (CIs) were obtained by logistic regression adjusted for age.

resultsWe found significant differences in the distribution of HDL-C, TG/HDL-C, and LDL-C/HDL-C between the patients and the control group (p < 0.05). In allele model and genotype model analysis, rs34861192, rs3219175, rs3745368, and rs1477341 could reduce the risk of steroid-induced ONFH. Further stratified analysis showed that rs3745367 was related to the clinical stage of patients, and rs1477341 was significantly correlated with an increased TG level and a decreased TC/HDL-C level. The linkage analysis showed that two SNPs (rs34861192 and rs3219175) in RETN even significant linkage disequilibrium.

conclusionsOur results provide the firstly evidence that RETN gene polymorphisms were associated with a reduced risk of steroid-induced ONFH in Chinese Han population.

Indexed as

AdultAsian PeopleCase-Control StudiesFemaleFemur Head NecrosisGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideResistinRisk FactorsResistinRETN protein, humanCase-control studyGenetic polymorphismsResistin (RETN)Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH)

Identifiers

PMID32143662
PMCPMC7060642
OpenAlexW3011998839

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.