Evidence map›Paper›PMID 32143292›Full record

ArticleCells2020

Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes.

Sonia Rodríguez-Fdez, Lucía Fernández-Nevado, L Francisco Lorenzo-Martín, Xosé R Bustelo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sonia Rodríguez-FdezCentro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain.
Lucía Fernández-NevadoCentro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain.
L Francisco Lorenzo-MartínCentro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain.
Xosé R BusteloCentro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain.
Universidad de Salamanca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vav1 works both as a catalytic Rho GTPase activator and an adaptor molecule. These functions, which are critical for T cell development and antigenic responses, are tyrosine phosphorylation-dependent. However, it is not known whether other posttranslational modifications can contribute to the regulation of the biological activity of this protein. Here, we show that Vav1 becomes acetylated on lysine residues in a stimulation- and SH2 domain-dependent manner. Using a collection of both acetylation- and deacetylation-mimicking mutants, we show that the acetylation of four lysine residues (Lys

Indexed as

AcetylationAnimalsChlorocebus aethiopsCOS CellsHumansJurkat CellsLysineNFATC Transcription FactorsPhosphorylationProtein BindingProtein Processing, Post-TranslationalProto-Oncogene Proteins c-vavSignal TransductionLysineNFATC Transcription FactorsProto-Oncogene Proteins c-vavVAV1 protein, humanacetylationadaptorguanosine nucleotide exchange factorJNKNFATRac1RhoT cell receptortyrosine phosphorylationVav

Identifiers

PMID32143292
PMCPMC7140538
OpenAlexW3009967163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.