ArticleNeuropharmacology2020
GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn.
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Article in Neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
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- Neuro-immune Crosstalk in Atopic Dermatitis: A Multiaxial Regulatory Network and Novel Therapeutic Perspectives.Clinical reviews in allergy & immunology · 2026Review
- Spatial transcriptomics reveals organizational properties of mouse spinal cord and alterations in neuropathic pain.bioRxiv : the preprint server for biology · 2026Article
- Astrocytic LCN2 drives uremic pruritus and morphine-induced pruritus via the GRP/GRPR pathway.Clinical and experimental nephrology · 2025Article
- Article
- Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Developing a Novel Method for the Analysis of Spinal Cord-Penile Neurotransmission Mechanisms.International journal of molecular sciences · 2023Article
- Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system.Frontiers in molecular neuroscience · 2023Article
- Characterization of the expression of gastrin-releasing peptide and its receptor in the trigeminal and spinal somatosensory systems of Japanese macaque monkeys: Insight into humans.The Journal of comparative neurology · 2022Article
- Critical Players and Therapeutic Targets in Chronic Itch.International journal of molecular sciences · 2022Review
- Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch.Nature communications · 2022Article
- Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.Biochemical pharmacology · 2022Article
- Article
- The Role of CNTNAP2 in Itch Sensation.The Journal of investigative dermatology · 2022Article
- Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.Pharmacology research & perspectives · 2021Article
- Article
- In Vivo Electrophysiology of Peptidergic Neurons in Deep Layers of the Lumbar Spinal Cord after Optogenetic Stimulation of Hypothalamic Paraventricular Oxytocin Neurons in Rats.International journal of molecular sciences · 2021Article
- Identification of potential biomarkers for abdominal pain in IBS patients by bioinformatics approach.BMC gastroenterology · 2021Article
- The Role of Gut Microbiota in Chronic Itch-Evoked Novel Object Recognition-Related Cognitive Dysfunction in Mice.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Norikazu KiguchiDepartment of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, 641-0012, Japan. Electronic address: kiguchi@wakayama-med.ac.jp.
Daisuke UtaDepartment of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama City, Toyama, 930-0194, Japan.
Huiping DingDepartment of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Hitoshi UchidaDepartment of Cellular Neuropathology, Brain Research Institute Niigata University, Niigata City, Niigata, 951-8585, Japan.
Fumihiro SaikaDepartment of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, 641-0012, Japan.
Shinsuke MatsuzakiDepartment of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, 641-0012, Japan.
Yohji FukazawaDepartment of Anatomy, Kansai University of Health Sciences, Sennan-gun, Osaka, 590-0482, Japan.
Manabu AbeDepartment of Animal Model Development, Brain Research Institute, Niigata University, Niigata City, Niigata, 951-8585, Japan.
Kenji SakimuraDepartment of Animal Model Development, Brain Research Institute, Niigata University, Niigata City, Niigata, 951-8585, Japan.
Mei-Chuan KoDepartment of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA; W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC, 28144, USA.
Shiroh KishiokaDepartment of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, 641-0012, Japan.
Wakayama Medical University · JPNiigata University · JPWake Forest University · USKansai University of Nursing and Health Sciences · JPUniversity of Toyama · JP
Funding
Diverse Effects of a Stress-Related Ligand, Corticotropin-Releasing Factor, in Non-Human PrimatesR21DA044450 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KO, MEI-CHUAN · 2018 to 2019
$426kEffects of a G protein-biased mu opioid receptor agonist PZM21 in primatesR21DA044775 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KO, MEI-CHUAN · 2017 to 2018
$425kSpinal BNP-NPRA Signaling in Regulating Itch and Pain in PrimatesR21AR069861 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KO, MEI-CHUAN · 2018 to 2019
$375kNIAMS NIH HHS R21 AR069861NIDA NIH HHS R21 DA044450NIDA NIH HHS R21 DA044775
Abstract
Gastrin-releasing peptide (GRP) receptor-expressing (GRPR)
Indexed as
AnimalsBombesinCyclopropanesDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsMacaca mulattaMaleMiceMice, Inbred C57BLMice, Inbred ICRNeuronsPeptide FragmentsPruritusReceptors, AMPAReceptors, BombesinSpinal Cord Dorsal HornBombesinbombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-CyclopropanesdiphenylcyclopropenoneExcitatory Amino Acid AntagonistsPeptide FragmentsReceptors, AMPAReceptors, BombesinChloroquineGlutamateHistamineNonhuman primatePainPruritus
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.