ArticleCancer cell2020
Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.
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Article in Cancer cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
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Who cites it
52 citing papers in PubMed, 93 citations in OpenAlex.
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- Diffuse Midline Gliomas: Clinical, Diagnostic, and Therapeutic Perspectives.Biomedicines · 2026Review
- Targeting aberrant DNA methylation across subtypes of pediatric high-grade glioma inhibits tumor growth and RUNX3 represents a targetable methylated tumor suppressor.Cell communication and signaling : CCS · 2026Article
- Modeling diffuse midline glioma through triple-electrode in utero electroporation of the developing mouse pons.PloS one · 2026Article
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- The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma.Cell death and differentiation · 2025Article
- Current Landscape of Preclinical Models for Pediatric Gliomas: Clinical Implications and Future Directions.Cancers · 2025Review
- Advancements in mechanisms and drug treatments for fibrodysplasia ossificans progressiva.Journal of Zhejiang University. Science. B · 2025Review
- An oncohistone-driven H3.3K27M/CREB5/ID1 axis maintains the stemness and malignancy of diffuse intrinsic pontine glioma.Nature communications · 2025Article
- Epigenetic reprogramming in pediatric gliomas: from molecular mechanisms to therapeutic implications.Trends in cancer · 2024Review
- Article
- Roles of Histone H2B, H3 and H4 Variants in Cancer Development and Prognosis.International journal of molecular sciences · 2024Review
- The Landscape of Pediatric High-Grade Gliomas: The Virtues and Pitfalls of Pre-Clinical Models.Biology · 2024Review
- Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma.Cancer cell · 2024Article
- H3K27M mutant glioma: Disease definition and biological underpinnings.Neuro-oncology · 2024Review
- The prognostic value and potential immunotherapeutic efficacy ofJournal of gastrointestinal oncology · 2024Article
- BMP signaling in cancer stemness and differentiation.Cell regeneration (London, England) · 2023Review
- Small-Molecule Probes as Pharmacological Tools for the Bone Morphogenetic Protein Signaling Pathway.ACS pharmacology & translational science · 2023Review
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 4 countries.
Jerome FortinPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address: jerome.fortin@uhnresearch.ca.
Ruxiao TianPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Ida ZarrabiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Graham HillPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Eleanor WilliamsStructural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.
Gonzalo Sanchez-DuffhuesDepartment of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, P.O. Box 9600 RC, Leiden, the Netherlands.
Midory ThorikayDepartment of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, P.O. Box 9600 RC, Leiden, the Netherlands.
Parameswaran RamachandranPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Robert SiddawayThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G1X8, Canada.
Jong Fu WongStructural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.
Annette WuPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Lorraine N ApuzzoDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06268, USA.
Jillian HaightPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Annick You-TenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Bryan E SnowPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Andrew WakehamPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
David J GoldhamerDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06268, USA.
Daniel SchramekCenter for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Alex N BullockStructural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.
Peter Ten DijkeDepartment of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, P.O. Box 9600 RC, Leiden, the Netherlands.
Cynthia HawkinsThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G1X8, Canada; Division of Pathology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Tak W MakPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address: tmak@uhnresearch.ca.
University Health Network · CAPrincess Margaret Cancer Centre · CALeiden University Medical Center · NLGenomics (United Kingdom) · GBUniversity of Connecticut · USHospital for Sick Children · CAMount Sinai Hospital · CAUniversity of Oxford · GBUniversity of Toronto · CA
Funding
Function of Fibro-Adipogenic Progenitors in Heterotopic Ossification of Skeletal MuscleR01AR072052 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI GOLDHAMER, DAVID J · 2017 to 2021
$1.7MNIAMS NIH HHS R01 AR072052Wellcome TrustWellcome Trust 106169/ZZ14/Z
Abstract
Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Some of these tumors combine gain-of-function mutations in ACVR1, PIK3CA, and histone H3-encoding genes. The oncogenic mechanisms of action of ACVR1 mutations are currently unknown. Using mouse models, we demonstrate that Acvr1
Indexed as
MutationActivin Receptors, Type IAnimalsBasic Helix-Loop-Helix ProteinsBone Morphogenetic ProteinsBrain NeoplasmsCell DifferentiationCell Line, TumorClass I Phosphatidylinositol 3-KinasesFemaleGliomaHistonesHumansLactonesMaleMice, Transgenic14-(ethylamino)-8,9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dioneActivin Receptors, Type IACVR1 protein, humanAcvr1 protein, mouseASCL1 protein, humanBasic Helix-Loop-Helix ProteinsBone Morphogenetic ProteinsClass I Phosphatidylinositol 3-KinasesH3c2 protein, mouseHistonesLactonesPik3ca protein, mouseReceptor, Platelet-Derived Growth Factor alphaSOX11 protein, humanSOXC Transcription FactorsACVR1bone morphogenetic proteinbrain cancercancer therapeuticdiffuse intrinsic pontine gliomaE6201gliomaHIST1H3BoligodendrocytePIK3CA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.