ArticleNeuron2020
An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- A connectome and analysis of the adulteLife · 2020Pooled it
- Thalamic Activity Regulates Interneuron Density in the Developing Visual Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- vEMRec: High-Resolution Volume Electron Microscopy Reconstruction Based on Structure-Preserving and High-Fidelity 3D Alignment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- vEMINR: Ultra-Fast Isotropic Reconstruction for Volume Electron Microscopy With Implicit Neural Representation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Differential topographic organization and retinal inheritance of direction and orientation selectivity in the visual thalamus.Nature communications · 2025Article
- Local thalamic interneurons drive spindle termination and enable sleep-dependent learning.bioRxiv : the preprint server for biology · 2025Article
- Article
- GABAergic Projections from the Pretectum Boost Retinogeniculate Signal Transfer via Disinhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features.Neuron · 2024Article
- Subcellular pathways through VGluT3-expressing mouse amacrine cells provide locally tuned object-motion-selective signals in the retina.Nature communications · 2024Article
- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- The type of inhibition provided by thalamic interneurons alters the input selectivity of thalamocortical neurons.Current research in neurobiology · 2024Article
- Connectomics of theeLife · 2023Article
- Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.Cell reports · 2023Article
- The connectome of an insect brain.Science (New York, N.Y.) · 2023Article
- 3D electron microscopy and volume-based bouton sorting reveal the selectivity of inputs onto geniculate relay cell and interneuron dendrite segments.Frontiers in neuroanatomy · 2023Article
- The parabigeminal nucleus is a source of "retinogeniculate replacement terminals" in mice that lack retinofugal input.The Journal of comparative neurology · 2022Article
- Volume electron microscopy.Nature reviews. Methods primers · 2022Article
- Genetic regulation of central synapse formation and organization in Drosophila melanogaster.Genetics · 2022Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
One way to assess a neuron's function is to describe all its inputs and outputs. With this goal in mind, we used serial section electron microscopy to map 899 synaptic inputs and 623 outputs in one inhibitory interneuron in a large volume of the mouse visual thalamus. This neuron innervated 256 thalamocortical cells spread across functionally distinct subregions of the visual thalamus. All but one of its neurites were bifunctional, innervating thalamocortical and local interneurons while also receiving synapses from the retina. We observed a wide variety of local synaptic motifs. While this neuron innervated many cells weakly, with single en passant synapses, it also deployed specialized branches that climbed along other dendrites to form strong multi-synaptic connections with a subset of partners. This neuron's diverse range of synaptic relationships allows it to participate in a mix of global and local processing but defies assigning it a single circuit function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.