Evidence map›Paper›PMID 32142599›Full record

ArticleThoracic cancer2020

Does surgically resected small-cell lung cancer without lymph node involvement benefit from prophylactic cranial irradiation?

Yuqing Lou, Runbo Zhong, Jianlin Xu, Rong Qiao, Jiajun Teng, Yanwei Zhang, Xueyan Zhang, Tianqing Chu, Hua Zhong, Baohui Han

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In one paragraph

Article in Thoracic cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. New perspectives in the management of small cell lung cancer.World journal of clinical oncology · 2022
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuqing LouDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0001-9218-2718
Runbo ZhongDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0003-4616-1224
Jianlin XuDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Rong QiaoDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jiajun TengDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yanwei ZhangDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xueyan ZhangDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Tianqing ChuDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Hua ZhongDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Baohui HanDepartment of Respiration, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-3950-3030

Funding

Key Projects of the Biomedicine Department, Science and Technology Commission of Shanghai Municipality 11411951200
6 · The paper itself

Abstract

backgroundIt has previously been demonstrated that surgically resected small-cell lung cancer (SCLC) patients could benefit from prophylactic cranial irradiation (PCI). However, PCI in patients without lymph node involvement remains controversial. This study includes a larger sample size to evaluate the benefit of PCI therapy in this specific population.

methodsThe records of surgically resected SCLC patients without lymph node involvement (N0M0) in Shanghai Chest Hospital were retrospectively reviewed.

resultsBetween January 2006 and May 2017, a total of 146 cases of surgically resected SCLC without lymph node involvement were included. A total of 46 patients received PCI therapy and 100 patients received no therapy. During the observation period, 12.0% (12/100) of the patients who did not receive PCI therapy developed brain metastases while 10.9% (5/46) of patients who received PCI therapy developed brain metastases. With regard to time to recurrence, no significant difference was observed among the groups (P = 0.798). Moreover, there was no significant difference in either the overall survival benefit (hazard ratio [HR] = 0.84, 95% confidence interval [CI]: 0.49-1.45, P = 0.532) or disease-free survival rate (HR = 0.95, 95% CI: 0.52-1.75, P = 0.864).

conclusionsThe evidence obtained does not support PCI therapy in the management of surgically resected SCLC with no lymph node involvement. KEY POINTS: Prophylactic cranial irradiation (PCI) remains controversial for resected small-cell lung cancer (SCLC) without lymph node involvement. In this study, the results indicated that PCI does not reduce the risk of cerebral recurrence of resected p-T1-2N0M0 SCLC. This is the largest sample size study focused on PCI in resected p-T1-2N0M0 SCLC. Future revised versions of the guidelines should address this issue.

Indexed as

Adenocarcinoma of LungAdultAgedAged, 80 and overBrain NeoplasmsCarcinoma, Squamous CellChinaCranial IrradiationFemaleFollow-Up StudiesHumansLung NeoplasmsLymph NodesMaleMiddle AgedNeoplasm Recurrence, LocalBrain metastasesprophylactic cranial irradiationresectedsmall cell lung cancer

Identifiers

PMID32142599
PMCPMC7180625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.