ArticlePloS one2020
Longitudinal trends in renal function among first time sugarcane harvesters in Guatemala.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Longitudinal Estimated GFR Trajectories Among Workers at High Risk for CKD of Unknown Etiology.Kidney international reports · 2025Article
- Article
- A Systems-Based Approach for the Prevention of Heat-Associated Kidney Disease in Latin American Workers.Annals of global health · 2025Article
- Longitudinal Renal Function Degradation Among Florida Agricultural Workers.Journal of occupational and environmental medicine · 2024Article
- A longitudinal assessment of heat exposure and biomarkers of kidney function on heat shock protein 70 and antibodies among agricultural workers.BMC nephrology · 2024Article
- Retention of Agricultural Workers Participating in a Renal Longitudinal Study.Journal of agromedicine · 2024Article
- Environmental and Social Factors Associated with High Chronic Kidney Disease Mortality Rates in Municipalities of Guatemala: An Ecological Study of Municipal-Level Mortality Data.International journal of environmental research and public health · 2023Article
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- Article
- Article
- Sugarcane Workweek Study: Risk Factors for Daily Changes in Creatinine.Kidney international reports · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
introductionChronic kidney disease of unknown origin (CKDu) is an epidemic concentrated in agricultural communities in Central and South America, including young, male sugarcane harvesters. The purpose of this analysis is to understand early changes in kidney function among a cohort of first-time sugarcane harvesters and to determine risk factors for kidney function decline.
methodsJoint latent class mixed models were used to model sub-population kidney function trajectory over the course of 4 years (2012-2016). Probability weighted logistic regression was used to determine personal health, community, and individual behavior risk factors associated with sub-population assignment. Data analysis occurred in 2019.
resultsOf 181 new workers median age 19 years old (IQR: 4), 39 (22%) were identified as having non-stable kidney function with an annual age-adjusted decline of estimated glomerular filtration rate (eGFR) of -1.0 ml/min per 1.73 m2 (95% CI: -3.4, 1.3). Kidney function (OR: 0.96; 95% CI: 0.93, 0.98), mild hypertension (OR: 5.21; 95% CI: 2.14, 13.94), and having a local home of residence (OR: 7.12; 95% CI: 2.41, 26.02) prior to employment in sugarcane were associated with non-stable eGFR sub-population assignment.
conclusionsMild hypertension may be an early indicator of the development of CKDu. A better understanding of preexisting risk factors is needed to determine why individuals are entering the workforce with reduced kidney function and elevated blood pressure and increased risk of renal function decline.
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