ArticleeLife2020
Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Comparative multi-omic analysis reveals conserved and derived mechanisms of fin and limb regeneration.Nature communications · 2026Article
- Optimized toolkit for the manipulation of immortalized axolotl fibroblasts.Methods (San Diego, Calif.) · 2025Article
- BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress.Nature communications · 2025Article
- The In Vitro Enhancement of Retinal Cell Viability via mInternational journal of molecular sciences · 2024Article
- Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish.eLife · 2024Article
- Amputation Triggers Long-Range Epidermal Permeability Changes in Evolutionarily Distant Regenerative Organisms.bioRxiv : the preprint server for biology · 2024Article
- Suppressors of cGAS-STING are downregulated during fin-limb regeneration and aging in aquatic vertebrates.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Review
- Making a new limb out of old cells: exploring endogenous cell reprogramming and its role during limb regeneration.American journal of physiology. Cell physiology · 2024Review
- Determinants of genetic diversity in Neotropical salamanders (Plethodontidae: Bolitoglossini).Ecology and evolution · 2023Article
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- A Practical Guide for CRISPR-Cas9-Induced Mutations in Axolotls.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Evolution and diversification of Mountain voles (Rodentia: Cricetidae).Communications biology · 2022Article
- Transposon control as a checkpoint for tissue regeneration.Development (Cambridge, England) · 2022Article
- The use of transgenics in the laboratory axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- The Axolotl's journey to the modern molecular era.Current topics in developmental biology · 2022Article
- Eya2 expression during mouse embryonic development revealed by Eya2Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Salamander Insights Into Ageing and Rejuvenation.Frontiers in cell and developmental biology · 2021Article
- The multi-functional eyes absent proteins.Critical reviews in biochemistry and molecular biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
How salamanders accomplish progenitor cell proliferation while faithfully maintaining genomic integrity and regenerative potential remains elusive. Here we found an innate DNA damage response mechanism that is evident during blastema proliferation (early- to late-bud) and studied its role during tissue regeneration by ablating the function of one of its components, Eyes absent 2. In
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.