Evidence map›Paper›PMID 32142369›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α.

Xiaoguang Sun, Belinda L Sun, Aleksandra Babicheva, Rebecca Vanderpool, Radu C Oita, Nancy Casanova, Haiyang Tang, Akash Gupta, Heather Lynn, Geetanjali Gupta and 10 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2025
    Article
  7. SOX17 in pulmonary arterial hypertension: from development to clinical phenotype.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  8. Signaling pathways and targeted therapy for pulmonary hypertension.Signal transduction and targeted therapy · 2025
    Review
  9. The Role of NADAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Review
  10. Article
  11. Review
  12. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Xiaoguang SunDepartment of Medicine.ORCID 0000-0003-4226-8294
Belinda L SunDepartment of Pathology, and.
Aleksandra BabichevaDepartment of Medicine.
Rebecca VanderpoolDepartment of Medicine.
Radu C OitaDepartment of Medicine.ORCID 0000-0003-1378-8936
Nancy CasanovaDepartment of Medicine.
Haiyang TangDepartment of Medicine.
Akash GuptaDepartment of Medicine.
Heather LynnDepartment of Medicine.ORCID 0000-0001-8259-2326
Geetanjali GuptaDepartment of Medicine.
Franz RischardDepartment of Medicine.
Saad SammaniDepartment of Medicine.
Carrie L KempfDepartment of Medicine.
Liliana Moreno-VinascoDepartment of Medicine.
Mohamed AhmedDepartment of Pediatrics, University of Arizona Health Sciences, Tucson, Arizona.
Sara M CampDepartment of Medicine.
Jian WangDepartment of Medicine.
Ankit A DesaiDepartment of Medicine.
Jason X-J YuanDepartment of Medicine.
Joe G N GarciaDepartment of Medicine.ORCID 0000-0002-6934-0420
University of Arizona · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
VENTILATOR ASSOCIATED LUNG INJURY: MOLECULAR APPROACHESP50HL073994 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BROWER, ROY G. · 2003 to 2007
$21.3M
Protein Chemistry & Biophysics CoreP01HL134610 · NHLBI · UNIVERSITY OF ARIZONA · PI BLACK, STEPHEN M · 2018 to 2022
$11.6M
Novel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8M
Pathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4M
NHLBI NIH HHS P01 HL134610NHLBI NIH HHS P50 HL073994NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R01 HL141387NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

We previously demonstrated involvement of

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCells, CulturedCytokinesDisease Models, AnimalEndothelial CellsEndothelial PAS Domain-Containing Protein 1FemaleGene Expression RegulationHumansHypertension, PulmonaryMaleNicotinamide PhosphoribosyltransferaseRatsSOX Transcription FactorsTranscription, GeneticBasic Helix-Loop-Helix ProteinsCytokinesEndothelial PAS Domain-Containing Protein 1Nicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanSOX Transcription Factorsendothelial-to-mesenchymal transitionhypoxia-inducible factor-2αnicotinamide phosphoribosyltransferasepromoter activitypulmonary arterial hypertension

Identifiers

PMID32142369
PMCPMC7328254
OpenAlexW3009874365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.