Evidence map›Paper›PMID 32141894›Full record

ReviewCurrent opinion in hematology2020

Vascular elastic fiber heterogeneity in health and disease.

Carmen M Halabi, Beth A Kozel

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Elastin, arterial mechanics, and stenosis.American journal of physiology. Cell physiology · 2022
    Review
  8. Elastic Fibre Proteins in Elastogenesis and Wound Healing.International journal of molecular sciences · 2022
    Review
  9. Extracellular Matrix in Aging Aorta.Frontiers in cell and developmental biology · 2022
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Carmen M HalabiDivision of Nephrology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Beth A KozelTranslational Vascular Medicine Branch, Laboratory of Vascular and Matrix Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
National Heart Lung and Blood Institute · USWashington University in St. Louis · US

Funding

Williams syndrome: A Translational Approach to Mechanism and TreatmentZIAHL006210 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KOZEL, BETH · 2016 to 2024
$10.4M
Modifiers of elastin arteriopathyZIAHL006212 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KOZEL, BETH · 2016 to 2024
$9.7M
Connective Tissue Mediated Vascular DiseaseZIAHL006244 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KOZEL, BETH · 2019 to 2024
$3.9M
Vascular Extracellular Matrix in Arterial Development and DiseaseK08HL135400 · NHLBI · WASHINGTON UNIVERSITY · PI HALABI, CARMEN M. · 2017 to 2020
$613k
Intramural NIH HHS ZIA HL006210Intramural NIH HHS ZIA HL006212Intramural NIH HHS ZIA HL006244NHLBI NIH HHS K08 HL135400
6 · The paper itself

Abstract

purpose of reviewElastin has historically been described as an amorphous protein that functions to provide recoil to tissues that stretch. However, evidence is growing that elastin's role may not be limited to biomechanics. In this minireview, we will summarize current knowledge regarding vascular elastic fibers, focusing on structural differences along the arterial tree and how those differences may influence the behavior of affiliated cells. RECENT

findingsRegional heterogeneity, including differences in elastic lamellar number, density and cell developmental origin, plays an important role in vessel health and function. These differences impact cell-cell communication, proliferation and movement. Perturbations of normal cell-matrix interactions are correlated with human diseases including aneurysm, atherosclerosis and hypertension. SUMMARY: Although classically described as a structural protein, recent data suggest that differences in elastin deposition along the arterial tree have important effects on heterotypic cell interactions and human disease.

Indexed as

ArteriesElastic TissueVascular DiseasesAnimalsElastinHumansElastin

Identifiers

PMID32141894
PMCPMC7325869
OpenAlexW3009690652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.