Evidence map›Paper›PMID 32141724›Full record

Trial reportThe Journal of clinical psychiatry2020

Early- Versus Adult-Onset Schizophrenia as a Predictor of Response to Neuroscience-Informed Cognitive Training.

Olga Puig, Melissa Fisher, Rachel Loewy, Kathleen Miley, Ian S Ramsay, Cameron S Carter, John D Ragland, Tara Niendam, Sophia Vinogradov

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00312962 phase1 / phase2completednot on this map

Neuroscience-Guided Remediation of Cognitive Deficits in Schizophrenia

TypeinterventionalSponsorUniversity of California, San FranciscoRan2004 to 2013Enrolled80ConditionsSchizophreniaArmsTargeted cognitive training (TCT), Computer games
NCT00694889 phase1 / phase2completednot on this map

Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia

TypeinterventionalSponsorUniversity of California, San FranciscoRan2007 to 2015Enrolled144ConditionsSchizophreniaArmsNeuroadaptive cognitive training, Computer games
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Childhood-Onset Psychosis: A large UK case series.European child & adolescent psychiatry · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Olga PuigDepartment of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Barcelona, Villarroel 170, 08036-Spain. opuig@clinic.ub.es.
Melissa FisherDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
Rachel LoewyDepartment of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Kathleen MileyDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
Ian S RamsayDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
Cameron S CarterDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, California, USA.
John D RaglandDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, California, USA.
Tara NiendamDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, California, USA.
Sophia VinogradovDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · USUniversity of California, Davis · USUniversity of California, San Francisco · US

Funding

Cognitive Remediation of Schizophrenia in a Community Mental Health SettingR01MH068725 · NIMH · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI VINOGRADOV, SOPHIA · 2004 to 2014
$4.9M
Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for PsychosisR01MH081051 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI VINOGRADOV, SOPHIA · 2008 to 2012
$2.4M
Brain-Plasticity Based Training for SchizophreniaR42MH073358 · NIMH · POSIT SCIENCE CORPORATION · PI MERZENICH, MICHAEL · 2005 to 2005
$140k
NIMH NIH HHS R01 MH068725NIMH NIH HHS R01 MH081051NIMH NIH HHS R42 MH073358
6 · The paper itself

Abstract

backgroundDevelopmental stages characterized by greater neural plasticity might be critical periods during which the effects of cognitive training (CT) could theoretically be maximized. However, experiencing a first episode of schizophrenia during childhood or adolescence (ie, early-onset schizophrenia [EOS]) may reduce the brain's ability to benefit from CT. This study examined the effects of EOS versus onset at > 18 years of age (ie, adult-onset schizophrenia [AOS]) as a predictor of response to CT and the relationship between duration of illness and cognitive improvements.

methodsThis study is a secondary analysis of data from 2 randomized trials that examined the cognitive effects of neuroscience-informed auditory training (AT) exercises in 84 outpatients with schizophrenia (26 EOS, 58 AOS, recruited between 2004 and 2014).

resultsThere was a significant effect of time in all cognitive domains (F > 10.22, P < .002). The effect of EOS was significant only for verbal learning and memory (F = 5.79, P = .018). AOS increased the mean change score by 5.70 points in this domain, whereas EOS showed no change (t = -2.280, P = .025). However, the difference between AOS and EOS was no longer statistically significant after control for multiple comparisons. Shorter duration of illness was associated with greater improvement in problem solving in the AOS group (r = -0.27, P = .040).

conclusionsAuditory training is effective in improving cognition in both EOS and AOS. Treatment effects in all cognitive domains were similar, with the exception of verbal learning and memory. This result requires replication. Cognitive training provided earlier in the course of the illness results in greater improvements in executive functions.

trial registrationClinicalTrials.gov identifiers: NCT00312962, NCT00694889​​.

Indexed as

Auditory PerceptionCognitive RemediationOutcome Assessment, Health CareVerbal LearningAdolescentAdultAge FactorsAge of OnsetChildCognitive DysfunctionHumansMiddle AgedNeuronal PlasticityNeurosciencesSchizophreniaYoung Adult

Identifiers

PMID32141724
PMCPMC8722522
OpenAlexW3010580089

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.