ArticleJournal of animal science2020
Combined signature of rumen microbiome and metabolome in dairy cows with different feed intake levels.
Article in Journal of animal science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of Oral Administration of Goat Rumen-Derived Bacterial Isolates on In Vitro and In Vivo Rumen Fermentation Characteristics.Animals : an open access journal from MDPI · 2026Article
- Ruminal archaea and bacteria metatranscriptomic responses to supplementation in steers fed low-quality forage.Journal of animal science · 2026Article
- Influence of host genetics on the functional composition of the rumen metagenome in beef cattle.Journal of animal science · 2026Article
- Associations Between Milk Composition, Blood Metabolomics, and Systemic Physiological Indices in High- vs. Low-Yielding Guanzhong Dairy Goats During Early Lactation.Veterinary sciences · 2025Article
- Rumen microbiota associated with feed efficiency in beef cattle are highly influenced by diet composition.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Ruminal digestion, gastrointestinal microbial profile, and metabolic pathways after the introduction of silicon-containing ultrafine particles into bull.Veterinary world · 2025Article
- Breed-Specific Responses and Ruminal Microbiome Shifts in Dairy Cows Under Heat Stress.Animals : an open access journal from MDPI · 2025Article
- Potential Role of Lauric Acid in Milk Fat Synthesis in Chinese Holstein Cows Based on Integrated Analysis of Ruminal Microbiome and Metabolome.Animals : an open access journal from MDPI · 2024Article
- Connecting the ruminant microbiome to climate change: insights from current ecological and evolutionary concepts.Frontiers in microbiology · 2024Review
- Effects of yeast culture supplementation on milk yield, rumen fermentation, metabolism, and bacterial composition in dairy goats.Frontiers in veterinary science · 2024Article
- Alterations in gut microbiota and metabolite profiles in patients with infantile cholestasis.BMC microbiology · 2023Article
- Heat Stress Induces Shifts in the Rumen Bacteria and Metabolome of Buffalo.Animals : an open access journal from MDPI · 2022Article
- Article
- The Response of Fecal Microbiota and Host Metabolome in Dairy Cows Following Rumen Fluid Transplantation.Frontiers in microbiology · 2022Article
- Mechanism of Action of Shenerjiangzhi Formulation on Hyperlipidemia Induced by Consumption of a High-Fat Diet in Rats Using Network Pharmacology and Analyses of the Gut Microbiota.Frontiers in pharmacology · 2022Article
- The OMICS of methane emissions.Journal of animal science · 2021Article
- Ruminal Degradation of Rumen-Protected Glucose Influences the Ruminal Microbiota and Metabolites in Early-Lactation Dairy Cows.Applied and environmental microbiology · 2021Article
- The Rumen Bacterial Community in Dairy Cows Is Correlated to Production Traits During Freshening Period.Frontiers in microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feed intake is a major factor in maintaining the balance between ruminal fermentation and the microbial community of dairy cows. To explore the relationship among feed intake, microbial metabolism, and ruminal fermentation, we examined the combined signatures of the microbiome and metabolome in dairy cows with different feed intake levels. Eighteen dairy cows were allocated to high feed intake (HFI), medium feed intake (MFI), and low feed intake (LFI) groups according to their average daily feed intake. 16S rDNA sequencing results revealed that the relative abundance of Firmicutes in the HFI group was significantly higher than that in the MFI and LFI groups (P < 0.05). The ratio of Bacteroidetes to Firmicutes was significantly lower in the HFI group than in the MFI and LFI groups (P < 0.05). The relative abundance of Lachnospiraceae_unclassified, Veillonellaceae_unclassified, and Saccharofermentants was significantly higher in the HFI group than in the LFI and MFI groups (P < 0.05). The relative abundance of Erysipelotrichaceae_unclassified and Butyrivibrio was significantly higher in the HFI group than in the MFI and LFI groups (P < 0.05). Ultra high performance liquid chromatography-mass spectrometry revealed five key pathways, including the linoleic acid metabolism pathway, alpha-linolenic acid metabolism, arginine and proline metabolism, glutathione metabolism, and valine, leucine, and isoleucine biosynthesis, which are closely related to energy and amino acid metabolism. Linoleic acid, glutamate, alpha-linolenic acid, l-methionine, and l-valine levels were significantly lower in the HFI group than in the MFI and LFI groups (q < 0.05), while the relative content of glutamate was significantly lower in the MFI group than in the LFI group (q < 0.05). Stearic acid content was significantly higher in the HFI group than in the LFI group (q < 0.05). Our findings provide insight into the rumen microbiome of dairy cows with different feed intake and the metabolic pathways closely associated with feed intake in early-lactating cows. The candidates involved in these metabolic pathways may be useful for identifying variations in feed intake. The signatures of the rumen microbiome and metabolome in dairy cows may help make decisions regarding feeding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.