Evidence map›Paper›PMID 32140976›Full record

SynthesisJournal of neuro-oncology2020

Epstein Barr virus associated smooth muscle tumors in the central nervous system: a case report and systematic review of the literature.

V M Willeke, M P Anderson, A Mahadevan, R Rojas, R Bhadelia, A J Thomas, E M Kasper

Abstract readCase ReportsSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Epstein-Barr Virus-Associated Smooth-Muscle Tumor of the Brain.AJNR. American journal of neuroradiology · 2024
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

V M WillekeDepartment of Neurological Surgery, Division of Neurosurgery at Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215-5400, USA.
M P AndersonDivision of Anatomic Pathology, Department of Pathology and Neurology at Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, E106, Boston, MA, 02215-5400, USA.
A MahadevanHematology and Oncology, Division of Radiation Oncology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA, 17822, USA.
R RojasDepartment of Radiology and Division of Neuroradiology at Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215-5400, USA.
R BhadeliaDepartment of Radiology and Division of Neuroradiology at Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215-5400, USA.
A J ThomasDepartment of Neurological Surgery, Division of Neurosurgery at Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215-5400, USA.
E M KasperDepartment of Surgery and Division of Neurosurgery, Hamilton Health Sciences Corp., Hamilton General Hospital, McMaster University, 237, Barton Street East, Hamilton, ON, 8L8 2X2, Canada. kaspere@hhsc.ca.ORCID http://orcid.org/0000-0002-7600-3051
Beth Israel Deaconess Medical Center · USGeisinger Medical Center · USHamilton General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEpstein Barr virus (EBV)-associated smooth muscle tumors (SMT) in the central nervous system are rare tumors. EBV-associated SMT mainly occur in patient with compromised immune status. We report on a case of a HIV positive patient, who developed multiple EBV-SMTs, intracranially and in the spine. We systematically review the literature on the topic. CASE REPORT: A 46 years old female with HIV was imaged for complaints of headaches for 2 years, when an intracranial lesion was found. The patient was followed with sequential MRI scans before an excision was performed 5 years later. Pathology revealed an EBV-associated SMT. Multiple other lesions appearing in the brain and in the spine over years were treated by stereotactic radiosurgery or by surgery. At the time of this report, the patient is alive under HARRT treatment without recurrence.

methodsA systematic PRISMA guided literature research was conducted on the topic reviewing multiple databases for EBV-associated SMT located in brain or spine. We identified 52 patients from the literature and performed a pooled analysis.

resultsAll patients in this cohort except one were immuno-suppressed from HIV, post-transplant therapy or because of CIS. Female predominance and a median age of 35 years was identified as was frequent multifocality. Therapeutic strategies varied but were mostly multidisciplinary with surgery.

conclusionBased on our results, EBV-associated SMT should be included in the differential diagnosis of intracranial lesions mimicking meningiomas in immuno-suppressed patients. Stereotactic radiosurgery can be offered as an alternate treatment option for suitable lesions. Long-term surveillance via MRI scanning is recommended for follow up.

Indexed as

Central Nervous System NeoplasmsEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansMiddle AgedPrognosisRadiosurgerySmooth Muscle TumorCentral nervous systemEBVHIVImmunosuppressionSmooth muscle tumor

Identifiers

PMID32140976
OpenAlexW3010549471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.