Evidence map›Paper›PMID 32140877›Full record

ArticleAIDS and behavior2020

Influences on Adherence to Antiretroviral Therapy (ART) in Early-Stage HIV Disease: Qualitative Study from Uganda and South Africa.

Norma C Ware, Monique A Wyatt, Emily E Pisarski, Bosco M Bwana, Catherine Orrell, Stephen Asiimwe, Gideon Amanyire, Nicholas Musinguzi, David R Bangsberg, Jessica E Haberer and 1 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Norma C WareDeparment of Medicine, Brigham and Women's Hospital, Boston, MA, USA. norma_ware@hms.harvard.edu.
Monique A WyattDeparment of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Ave., Boston, MA, 02115, USA.
Emily E PisarskiDeparment of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Ave., Boston, MA, 02115, USA.
Bosco M BwanaMbarara University of Science and Technology, Mbarara, Uganda.
Catherine OrrellDesmond Tutu HIV Foundation, Cape Town, South Africa.
Stephen AsiimweGlobal Health Collaborative, Mbarara, Uganda.
Gideon AmanyireGlobal Health Collaborative, Mbarara, Uganda.
Nicholas MusinguziGlobal Health Collaborative, Mbarara, Uganda.
David R BangsbergOregon Health and Science University-Portland State University School of Public Health, Portland, OR, USA.
Jessica E HabererDeparment of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Ave., Boston, MA, 02115, USA.
META Study Team

Funding

Bill and Melinda Gates Foundation OPP1056051
6 · The paper itself

Abstract

Realization of optimal treatment and prevention benefits in the era of universal antiretroviral therapy (ART) and "U=U" (undetectable = untransmittable) requires high adherence at all stages of HIV disease. This article draws upon qualitative interview data to characterize two types of influences on ART adherence for 100 Ugandans and South Africans initiating ART during early-stage HIV infection. Positive influences are: (a) behavioral strategies supporting adherence; (b) preserving health through adherence; (c) support from others; and (d) motivating effect of adherence monitoring. "De-stabilizing experiences" (mobility, loss, pregnancy) as barriers are posited to impact adherence indirectly through intervening consequences (e.g. exacerbation of poverty). Positive influences overlap substantially with adherence facilitators described for later-stage adherers in previous research. Adherence support strategies and interventions effective for persons initiating ART later in HIV disease are likely also to be helpful to individuals beginning treatment immediately upon confirmation of infection. De-stabilizing experiences merit additional investigation across varying populations.

Indexed as

Drug MonitoringSocial StigmaAdultAnti-HIV AgentsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBlack PeopleFemaleHealth Services AccessibilityHIV InfectionsHumansInterviews as TopicMaleMedication AdherenceMotivationPovertyAnti-HIV AgentsAnti-Retroviral AgentsART adherenceEarly HIV diseaseQualitative studyS. AfricaUganda

Identifiers

PMID32140877
PMCPMC11091710

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.