Evidence map›Paper›PMID 32140866›Full record

SynthesisJournal of neurology2020

Predictive factors of outcome in cervical dystonia following deep brain stimulation: an individual patient data meta-analysis.

Xing Hua, Bohan Zhang, Zhicheng Zheng, Houyou Fan, Linfeng Luo, Xiaosi Chen, Jian Duan, Dongwei Zhou, Meihua Li, Tao Hong and 1 more

Abstract readComparative StudyMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Arching deep brain stimulation in dystonia types.Journal of neural transmission (Vienna, Austria : 1996) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xing Hua *Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Bohan Zhang *Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Zhicheng ZhengThe Fourth Clinical Medical College of Nanchang University, Nanchang, Jiangxi, China.
Houyou FanDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Linfeng LuoDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Xiaosi ChenDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Jian DuanDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Dongwei ZhouDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Meihua LiDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Tao HongDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China.
Guohui LuDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, Nanchang, 330006, Jiangxi, China. guohui-lu@163.com.ORCID http://orcid.org/0000-0001-6713-0000
Nanchang University · CN

Funding

Natural Science Foundation of Jiangxi Province 20192BAB205042Science and Technology Project of Jiangxi Provincial Health and Family Planning Commission 20182257
6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) therapy has been suggested to be a beneficial alternative in cervical dystonia (CD) for patients who failed nonsurgical treatments. This individual patient data meta-analysis compared the efficacy of DBS in the globus pallidus internus (GPi) versus subthalamic nucleus (STN) and identified possible predictive factors for CD.

methodsThree electronic databases (PubMed, Embase and Web of Science) were searched for studies with no publication date restrictions. The primary outcomes were normalized by calculating the relative change in TWSTRS total scores and subscale scores at the last follow-up. Data were analyzed mainly using Pearson's correlation coefficients and a stepwise multivariate regression analysis.

resultsThirteen studies (86 patients, 58 with GPi-DBS and 28 with STN-DBS) were eligible. Patients showed significant improvement in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) (52.5 ± 11.6 vs 21.9 ± 14.9, P < 0.001) scores at the last follow-up (22.0 ± 14.3 months), compared with scores at baseline, with a mean improvement of 56.6% (P < 0.001) (54.9% in severity, 63.2% in disability, 41.7% in pain). There was no significant difference in the improvement (%) of the total TWSTRS scores in 3 years for the GPI and STN groups (58.1 ± 22.6 vs 47.5 ± 39.2, P > 0.05). Age at surgery and age at symptom onset were negatively correlated with the relative changes in TWSTRS scores at the last follow-up, while there was a positive correlation with preoperative TWSTRS scores. On the stepwise multivariate regression, only the age at surgery remained significant in the best predictive model.

conclusionsGPi-DBS and STN-DBS both provided a common great improvement in the symptoms of CD patients in 3 years. Earlier age at surgery may probably indicate larger improvement. More randomized large-scale clinical trials are warranted in the future.

Indexed as

Deep Brain StimulationGlobus PallidusOutcome Assessment, Health CareSubthalamic NucleusAdultAgedHumansMiddle AgedTorticollisCervical dystoniaDeep brain stimulationGlobus pallidus internusIndividual patient dataMeta-analysisPredictive factorsSubthalamic nucleus

Identifiers

PMID32140866
OpenAlexW3009115866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.