Evidence map›Paper›PMID 32140862›Full record

SynthesisSurgical endoscopy2020

Effectiveness and safety of EUS-guided choledochoduodenostomy using lumen-apposing metal stents (LAMS): a systematic review and meta-analysis.

Rajesh Krishnamoorthi, Chandra S Dasari, Viveksandeep Thoguluva Chandrasekar, Harshith Priyan, Mahendran Jayaraj, Joanna Law, Michael Larsen, Richard Kozarek, Andrew Ross, Shayan Irani

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  6. Role of Endoscopy in Malignant Biliary Obstruction.Diagnostics (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Rajesh KrishnamoorthiVirginia Mason Medical Center, Digestive Diseases Institute, Seattle, WA, USA. Rajesh.Krishnamoorthi@virginiamason.org.
Chandra S Dasari *Department of Gastroenterology and Hepatology, Kansas City VA Medical Center, Kansas City, USA.
Viveksandeep Thoguluva ChandrasekarDepartment of Gastroenterology and Hepatology, Kansas City VA Medical Center, Kansas City, USA.
Harshith PriyanGastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Mahendran JayarajUniversity of Nevada, Las Vegas, NV, USA.
Joanna LawVirginia Mason Medical Center, Digestive Diseases Institute, Seattle, WA, USA.
Michael LarsenVirginia Mason Medical Center, Digestive Diseases Institute, Seattle, WA, USA.
Richard KozarekVirginia Mason Medical Center, Digestive Diseases Institute, Seattle, WA, USA.
Andrew RossVirginia Mason Medical Center, Digestive Diseases Institute, Seattle, WA, USA.
Shayan IraniVirginia Mason Medical Center, Digestive Diseases Institute, Seattle, WA, USA.
Virginia Mason Medical Center · USKansas City VA Medical Center · USMayo Clinic in Arizona · USUniversity of Kansas Medical Center · USUniversity of Nevada, Las Vegas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic ultrasound-guided choledochoduodenostomy (CDD) is emerging as an alternative technique for biliary drainage in patients who fail conventional endoscopic retrograde cholangiopancreatography (ERCP). The lumen-apposing metal stents (LAMS) are being increasingly used for CDD. We performed a systematic review and meta-analysis to evaluate the effectiveness and safety of CDD using LAMS.

methodsWe performed a systematic search of multiple databases through May 2019 to identify studies on CDD using covered self-expanding metal stents. Pooled rates of technical success, clinical success, adverse events, and recurrent jaundice associated with CDD using LAMS were estimated. A subgroup analysis was performed based on use of LAMS with electrocautery-enhanced delivery system (EC-LAMS).

resultsSeven studies on CDD using LAMS (with 284 patients) were included in the meta-analysis. Pooled rates of technical and clinical success (per-protocol analysis) were 95.7% (95% CI 93.2-98.1) and 95.9% (95% CI 92.8-98.9), respectively. Pooled rate of post-procedure adverse events was 5.2% (95% CI 2.6-7.9). Pooled rate of recurrent jaundice was 8.7% (95% CI 4.5-12.8). On subgroup analysis of CDD using EC-LAMS (5 studies with 201 patients), the pooled rates of technical and clinical success (per-protocol analysis) were 93.8% (95% CI 90.4-97.1) and 95.9% (95% CI 91.9-99.9), respectively. Pooled rate of post-procedure adverse events was 5.6% (95% CI 1.7-9.5). Pooled rate of recurrent jaundice was 11.3% (95% CI 6.9-15.7). Heterogeneity (I

conclusionCDD using LAMS/EC-LAMS is an effective and safe technique for biliary decompression in patients who failed ERCP. Further studies are needed to assess CDD using LAMS as primary treatment modality for biliary obstruction.

Indexed as

Cholangiopancreatography, Endoscopic RetrogradeCholedochostomyCholestasisDrainageDuodenostomyElectrocoagulationEndosonographyHumansSelf Expandable Metallic StentsStentsTreatment OutcomeAdverse eventsEC-LAMS- electro-cautery-enhanced LAMSLAMS- lumen-apposing metal stentsMalignant biliary obstructionTechnical and clinical success

Identifiers

PMID32140862
OpenAlexW3009612892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.