ArticleSleep2020
Sex-specific association of poor sleep quality with gray matter volume.
Article in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Structural Brain Correlates of Insufficient Sleep in Adolescents: A Narrative Review of MRI Evidence.Children (Basel, Switzerland) · 2026Review
- Sleep as a moderator of adolescent brain development-evidence from a longitudinal MRI study.Sleep · 2026Article
- Sleep quality in Spanish adults: an age- and sex-stratified cross-sectional study.Scientific reports · 2025Observational
- Article
- Exploring the relationship of sleep duration on cognitive function among the elderly: a combined NHANES 2011-2014 and mendelian randomization analysis.BMC geriatrics · 2024Article
- Association between the Pittsburgh sleep quality index and white matter integrity in healthy adults: a whole-brain magnetic resonance imaging study.Sleep and biological rhythms · 2023Article
- Resting-state functional connectivity of the sensory/somatomotor network associated with sleep quality: evidence from 202 young male samples.Brain imaging and behavior · 2022Article
- Neural correlates of sleep quality in children: Sex-specific associations shown by brain diffusion tractography.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Association Between Sleep Duration and Intelligence Quotient in 6-Year-Old Children.International journal of behavioral medicine · 2022Article
- Disrupted Brain Functional Network Topology in Essential Tremor Patients With Poor Sleep Quality.Frontiers in neuroscience · 2022Article
- Gender Differences in Hippocampal/Parahippocampal Functional Connectivity Network in Patients Diagnosed with Chronic Insomnia Disorder.Nature and science of sleep · 2022Article
- Dynamic changes in fractional amplitude of low-frequency fluctuations in patients with chronic insomnia.Frontiers in neuroscience · 2022Article
- Article
- The Different Faces of Insomnia.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesPrevious studies were inconsistent with regard to the association of sleep dysfunction on the brain's gray matter volume (GMV). The current study set out to investigate if there is a moderating effect of sex on the relationship between sleep quality in healthy individuals and GMV.
methodsWe applied voxel-based morphometry in 1,074 young adults of the "Human Connectome Project." An analysis of variance with the factors "sleep quality" (good/poor according to the Pittsburgh Sleep Quality Index, cutoff >5) and "sex" (male, female) on GMV was conducted. Additionally, linear relationships between sleep quality and GMV were tested.
resultsThe analysis of variance yielded no main effect for sleep quality, but an interaction between sex and sleep quality for the right superior frontal gyrus. Post hoc t-tests showed that female good sleepers in comparison to female poor sleepers had larger GMV in the right parahippocampal gyrus extending to the right hippocampus (whole-brain family-wise error [FWE]-corrected), as well as smaller GMV in the right inferior parietal lobule (whole-brain FWE-corrected) and the right inferior temporal gyrus (whole brain FWE-corrected). There were no significant effects when comparing male good sleepers to male poor sleepers. Linear regression analyses corroborated smaller GMV in the right parahippocampal gyrus in women with poor sleep quality.
conclusionsPoor sleep quality was associated with altered GMV in females, but not in males. Future studies are needed to investigate the neurobiological mechanisms that underlie the sex differences in the association of sleep quality and brain differences found in this study.
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