ArticleEClinicalMedicine2020
Concurrent prenatal drinking and smoking increases risk for SIDS: Safe Passage Study report.
Article in EClinicalMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the burden and risk factors of sudden infant death syndrome (SIDS) in Africa.Journal of global health · 2021Pooled it
- Nicotine Exposure During Gestation: From Placental Dysfunction to Long-Term Neurobehavioral Outcomes.Birth defects research · 2026Review
- Substance use patterns among individuals who consume alcohol during pregnancy: Results from a US multi-site study.Drug and alcohol dependence · 2026Article
- Clinical Features of Typically Developing Children with and without Prenatal Alcohol Exposure.The Journal of pediatrics · 2025Article
- The Changing Epidemiology of Sudden Infant Death Syndrome: A 15-Year Overview Comparing Italian and European Data.Health science reports · 2025Article
- Serotonergic receptor binding in the brainstem in the Sudden Infant Death Syndrome in a high-risk population.PloS one · 2025Article
- Risk factors for small for gestational age as defined by a birthweight z-score below minus one: A prospective observational study.Medical research archives · 2024Article
- In Utero Exposure to Alcohol and Tobacco and Electroencephalogram Power During Childhood.JAMA network open · 2024Article
- Maternal and paternal risk factors for fetal alcohol spectrum disorders: Alcohol and other drug use as proximal influences.Alcohol, clinical & experimental research · 2023Article
- Associations between prenatal alcohol and tobacco exposure on Doppler flow velocity waveforms in pregnancy: a South African study.BMC pregnancy and childbirth · 2023Article
- Fetal alcohol spectrum disorders prevention and clinical guidelines research-workshop report.BMC proceedings · 2023Article
- Review
- Qualitative assessment of infant sleep practices and other risk factors of sudden infant death syndrome (SIDS) among mothers in Lusaka, Zambia.BMC pediatrics · 2023Article
- Machine learning-based placental clusters and their associations with adverse pregnancy outcomes.Paediatric and perinatal epidemiology · 2023Article
- Dose-response association between maternal smoking during pregnancy and the risk of infant death: a nationwide, population-based, retrospective cohort study.EClinicalMedicine · 2023Article
- Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023Review
- Low to Moderate Prenatal Alcohol Exposure and Neurodevelopmental Outcomes: A Narrative Review and Methodological Considerations.Alcohol research : current reviews · 2023Review
- Prenatal smoking and drinking are associated with altered newborn autonomic functions.Pediatric research · 2023Article
- Prenatal cannabis use disorder and infant hospitalization and death in the first year of life.Drug and alcohol dependence · 2023Article
- Maternal, infant, and environmental risk factors for sudden unexpected infant deaths: results from a large, administrative cohort.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
Corrections and comments
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Authors and funding
32 authors.
Funding
Abstract
backgroundSudden infant death syndrome (SIDS) is the leading cause of postneonatal mortality. Although the rate has plateaued, any unexpected death of an infant is a family tragedy thus finding causes and contributors to risk remains a major public health concern. The primary objective of this investigation was to determine patterns of drinking and smoking during pregnancy that increase risk of SIDS.
methodsThe Safe Passage Study was a prospective, multi-center, observational study with 10,088 women, 11,892 pregnancies, and 12,029 fetuses, followed to 1-year post delivery. Subjects were from two sites in Cape Town, South Africa and five United States sites, including two American Indian Reservations. Group-based trajectory modeling was utilized to categorize patterns of drinking and smoking exposure during pregnancy.
findingsOne-year outcome was ascertained in 94·2% infants, with 28 SIDS (2·43/1000) and 38 known causes of death (3·30/1000). The increase in relative risk for SIDS, adjusted for key demographic and clinical characteristics, was 11·79 (98·3% CI: 2·59-53·7,
interpretationInfants prenatally exposed to both alcohol and cigarettes continuing beyond the first trimester have a substantially higher risk for SIDS compared to those unexposed, exposed to alcohol or cigarettes alone, or when mother reported quitting early in pregnancy. Given that prenatal drinking and smoking are modifiable risk factors, these results address a major global public health problem.
fundingNational Institute on Alcohol Abuse and Alcoholism,
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