Evidence map›Paper›PMID 32140655›Full record

ArticleHepatology communications2020

Woolly Monkey-HBV Infection in Squirrel Monkeys as a Surrogate Nonhuman Primate Model of HBV Infection.

Christopher Y Chen, Benjamin Y Winer, Deborah Chavez, Bernadette Guerra, Kathleen M Brasky, Stacey Eng, Eduardo Salas, Danny Tam, Joe H Simmons, Christian R Abee and 4 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Christopher Y ChenSouthwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX.
Benjamin Y WinerDepartment of Molecular Biology Princeton University Princeton NJ.
Deborah ChavezSouthwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX.
Bernadette GuerraSouthwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX.
Kathleen M BraskySouthwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX.
Stacey EngGilead Biosciences, Inc. Foster City CA.
Eduardo SalasGilead Biosciences, Inc. Foster City CA.
Danny TamGilead Biosciences, Inc. Foster City CA.
Joe H SimmonsDepartment of Comparative Medicine Michale E. Keeling Center for Comparative Medicine and Research of the University of Texas MD Anderson Center Bastrop TX.
Christian R AbeeDepartment of Comparative Medicine Michale E. Keeling Center for Comparative Medicine and Research of the University of Texas MD Anderson Center Bastrop TX.
William E DelaneyGilead Biosciences, Inc. Foster City CA.
Alexander PlossDepartment of Molecular Biology Princeton University Princeton NJ.ORCID https://orcid.org/0000-0001-9322-7252
Robert E LanfordSouthwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX.
Christian VoitenleitnerGilead Biosciences, Inc. Foster City CA.
Gilead Sciences (United States) · USTexas Biomedical Research Institute · USPrinceton University · USThe University of Texas MD Anderson Cancer Center · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Squirrel Monkey Breeding and Research Resource: Resource CoreP40OD010938 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WILLIAM D HOPKINS · 2012 to 2026
$14.9M
NIH HHS P40 OD010938NIH HHS P51 OD011133
6 · The paper itself

Abstract

Development of curative therapies for chronic hepatitis B virus (HBV) infection will likely require new animal models. Here, we evaluate HBV infection in squirrel monkeys based on the high-sequence homology of the HBV receptor, Na+/taurocholate co-transporting peptide (NTCP), between humans and squirrel monkeys. HBV PreS1 peptide was examined for binding human and squirrel monkey NTCP. Immunodeficient

Identifiers

PMID32140655
PMCPMC7049680
OpenAlexW2998532050

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.