ArticleHeliyon2020
Human papillomavirus type 16 and 18 viral loads as predictors associated with abnormal cervical cytology among women in Saudi Arabia.
Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Prevalence and genotypes' distribution of human papillomavirus among women in Saudi Arabia: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Cytomorphologic Findings Associated With High-Risk HPV Categories in PAP Smears.Diagnostic cytopathology · 2026Article
- Correlation between viral load and cervical squamous lesion severity in single and multiple infections: a large-scale analysis.Infectious agents and cancer · 2026Article
- Knowledge and attitude toward Pap smear, human papilloma virus, and human papilloma virus vaccine among Saudi women.Journal of family medicine and primary care · 2026Article
- Association between HPV-16 and HPV-18 viral loads and severity of cervical pre-invasive lesions in women with and without HIV in Botswana.Frontiers in oncology · 2026Article
- Genotypic distribution and molecular epidemiology of HPV in women in the UAE using PNA-based RT PCR.PloS one · 2026Article
- Parental knowledge, attitudes, and hesitancy toward human papillomavirus vaccination in Saudi Arabia: an online cross-sectional study.Frontiers in medicine · 2026Article
- Awareness and knowledge of human papillomavirus, vaccine acceptability and cervical cancer among college students in Saudi Arabia.Human vaccines & immunotherapeutics · 2024Article
- Human papillomavirus prevalence and genotypes in Gulf Cooperation Council countries: A scoping review 2017-2024.Qatar medical journal · 2024Article
- HPV Vaccine Uptake, Willingness to Receive, and Causes of Vaccine Hesitancy: A National Study Conducted in Saudi Arabia Among Female Healthcare Professionals.International journal of women's health · 2024Article
- Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women in Saudi Arabia.Viruses · 2022Article
- Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection.BMC infectious diseases · 2022Article
- Human Papillomavirus Knowledge and Vaccine Acceptability in Jazan Province, Saudi Arabia.Vaccines · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The detection of HPV viral DNA is regularly conducted with cervical screening. However, using a molecular marker such as the viral load may serve as a predictor associated with disease detection and progression. The present study aimed to screen for and genotype HPV among women in Saudi Arabia, develop and validate sensitive quantitative polymerase chain reaction (qPCR) assays to detect viral load for the two most common HPV types, namely 16 and 18, and assess whether HPV viral load could be used as a marker for cervical abnormality and disease progression. This study examined 733 specimens (both formalin-fixed paraffin embedded specimens and PAP smear samples) from women who underwent cervical screening. The specimens and samples were processed for DNA extraction and then tested for HPV DNA using nested PCR. Approximately 165 specimens (18%) were positive for HPV. Those specimens were genotyped using a reverse line blotting hybridization assay. The results indicated that the most common HPV types detected were a single infection with HPV 16 (51%) or with HPV 18 (28%) followed by infections with multiple HPV types (~7%). A qPCR TaqMan assay developed and validated in-house was used to determine viral load for HPV genotypes 16 (n = 80) and 18 (n = 45). Viral loads for both HPV types were significantly associated with cervical cytology grade (
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Registered trials
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