Evidence map›Paper›PMID 32140439›Full record

ArticleMethodsX2020

A method to dissolve 3-MCPD mono- and di-esters in aqueous cell culture media.

Mapa S T Mapa, Magali Araujo, Yang Zhao, Thomas Flynn, Jessica Sprando, Paddy Wiesenfeld, Robert L Sprando, Miriam E Mossoba

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MethodsX, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mapa S T MapaDivision of Applied Regulatory Toxicology (DART), Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition (CFSAN), U.S. Food and Drug Administration (US FDA), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Magali AraujoDivision of Applied Regulatory Toxicology (DART), Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition (CFSAN), U.S. Food and Drug Administration (US FDA), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Yang ZhaoDivision of Applied Regulatory Toxicology (DART), Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition (CFSAN), U.S. Food and Drug Administration (US FDA), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Thomas FlynnDivision of Applied Regulatory Toxicology (DART), Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition (CFSAN), U.S. Food and Drug Administration (US FDA), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Jessica SprandoVirginia-Maryland College of Veterinary Medicine, 205 Duck Pond Road, Blacksburg, VA 24061, United States.
Paddy WiesenfeldDivision of Applied Regulatory Toxicology (DART), Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition (CFSAN), U.S. Food and Drug Administration (US FDA), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Robert L SprandoDivision of Applied Regulatory Toxicology (DART), Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition (CFSAN), U.S. Food and Drug Administration (US FDA), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Miriam E MossobaDivision of Applied Regulatory Toxicology (DART), Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition (CFSAN), U.S. Food and Drug Administration (US FDA), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Center for Food Safety and Applied Nutrition · USUnited States Food and Drug Administration · USVirginia–Maryland College of Veterinary Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatty acid esters of 3-monochloropropane-1,2-diol (3-MCPD) are chemical contaminants found in a wide range of edible oils that are thermally processed during industrial manufacturing of infant formula and other lipid-containing foods in the United States. Rodent studies have unequivocally demonstrated a plethora of

Indexed as

3-Monochloropropane-1,2-diol estersFree fatty acidsIn vitro cell cultureSolubilizationThree-step protocol to dissolve 3-MCPD esters and free fatty acids in aqueous cell culture media

Identifiers

PMID32140439
PMCPMC7046810
OpenAlexW2995659450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.