Evidence map›Paper›PMID 32140401›Full record

ArticleJournal of bone oncology2020

Prognostic factors in osteosarcoma: A study level meta-analysis and systematic review of current practice.

Sun Xin, Guo Wei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sun XinOrthopedic Oncology, Peking University People's Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Guo WeiOrthopedic Oncology, Peking University People's Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Peking University People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA consensus has not yet been reached regarding the abilities of gender, age, tumor size, tumor location, histologic subtypes, and surgery in the prediction of survival in osteosarcoma. We aimed to disclose their prognostic significance by conducting a meta-analysis of all the published data from the last decade. MATERIALS AND

methodsElectronic database searches were conducted in PubMed, Embase, and Web of Science for relevant articles published within the last ten years. The pooled hazard ratio (HR) and corresponding 95% confidence interval (CI) were obtained to evaluate the prognostic values of the target factors.

resultsA total of 18,126 patients from 40 studies were eventually included. Results indicated that gender (male vs. female: 1.21, 95% CI, 1.11-1.32; female vs. male: 0.85, 95% CI, 0.75-0.98), age (12-20 vs. ≤12: 1.37, 95% CI, 1.13-1.65; ≥20 vs. <20: 1.29, 95% CI, 1.08-1.55; ≥40 vs. <40: 1.63, 95% CI, 1.21-2.20; ≥50 vs. <25: 2.60, 95% CI, 1.92-3.53; ≥60 vs. <60: 1.11, 95% CI, 1.06-1.18), tumor location (non-extremities vs. extremities: 2.10, 95% CI, 1.76-2.51; proximal vs. distal femur: 3.68, 95% CI: 1.51-8.96; proximal vs. distal humerus: 3.15, 95% CI: 1.53-6.49), tumor size (≥5 vs. <5: 1.42, 95% CI, 1.09-1.86; >8 vs. ≤8: 1.55, 95% CI, 1.07-2.24; >9 vs. ≤9: 1.44, 95% CI, 1.05-1.96), chemotherapy response (poor vs. good: 2.45, 95% CI, 2.02-2.97; good vs. poor: 0.41, 95% CI, 0.34-0.48), and surgery (yes vs. no: 0.45, 95% CI, 0.36-0.57; amputation vs. salvage: 2.34, 95% CI, 1.47-3.74) were significantly associated with overall survival in osteosarcoma patients.

conclusionThe meta-analysis demonstrated that male patients, older age, large tumor size, non-extremity osteosarcoma, proximal osteosarcoma, poor chemotherapy response, no surgical treatment, and amputation surgery were correlated with a poor prognosis in osteosarcoma patients.

Indexed as

ClinicopathologyMeta-analysisOsteosarcomaPrognosis

Identifiers

PMID32140401
PMCPMC7047183
OpenAlexW3006362810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.