Evidence map›Paper›PMID 32140393›Full record

ArticleActa pharmaceutica Sinica. B2020

Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice.

Xueqin Yang, Dongke Yu, Li Xue, Hui Li, Junrong Du

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 3 syntheses or guidelines pooled it, 385 citations in OpenAlex.

  1. Pooled it
  2. Nutrients · 2025
    Pooled it
  3. Probiotic supplementation improved cognitive function in cognitively impaired and healthy older adults: a systematic review of recent trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  4. Effect ofInternational journal of medical sciences · 2026
    Trial
  5. Efficacy and Safety ofNutrients · 2025
    Trial
  6. Trial
  7. ProbioticNutrients · 2022
    Trial
  8. Trial
  9. Article
  10. The effects ofIBRO neuroscience reports · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xueqin YangDepartment of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Dongke YuDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China.
Li XueDepartment of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Hui LiDepartment of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Junrong DuDepartment of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Sichuan University · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ProBiotic-4 is a probiotic preparation composed of

Indexed as

8-OHdG, 8-hydroxydesoxyguanosineAAMI, age-associated memory impairmentAD, Alzheimer's diseaseBBB, blood–brain barrierCFU, colony-forming unitsCognitive declineELISA, enzyme-linked immunosorbent assayF/B, Firmicutes/BacteroidetesGFAP, glial fibrillary acidic proteinHE, hematoxylin and eosinIba-1, ionized calcium binding adaptor molecule-1IHC, immunohistochemistryIL-6, interleukin-6LPS, lipopolysaccharideMCI, mild cognitive impairmentMicrobiota–gut–brain axisNF-κBNF-κB, nuclear factor-κBNMDS, non-metric multidimensional scalingOTU, operational taxonomic unitPAMP, pathogen-associated molecular patternProbioticsRIG-IRIG-I, retinoic-acid-inducible gene-ISAMP8 miceSAMP8, senescence-accelerated mouse prone 8SYN, synaptophysinTEM, transmission electron microscopyTLR4TLR4, toll-like receptor 4TNF-α, tumor necrosis factor-αVE-cadherin, vascular endothelial-cadherinZO-1, zona occluden-1

Identifiers

PMID32140393
PMCPMC7049608
OpenAlexW2954864461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.