Evidence map›Paper›PMID 32140156›Full record

ArticleFrontiers in immunology2020

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8

Louise C Rowntree, Heleen van den Heuvel, Jessica Sun, Lloyd J D'Orsogna, Thi H O Nguyen, Frans H J Claas, Jamie Rossjohn, Tom C Kotsimbos, Anthony W Purcell, Nicole A Mifsud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Design of solubly expressed miniaturized SMART MHCs.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. TCR_Explore: A novel webtool for T cell receptor repertoire analysis.Computational and structural biotechnology journal · 2023
    Article
  5. Review
  6. Observational
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Louise C RowntreeRespiratory Medicine Laboratory, Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Heleen van den HeuvelInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Jessica SunInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Lloyd J D'OrsognaDepartment of Clinical Immunology and Pathwest, Fiona Stanley Hospital, Perth, WA, Australia.
Thi H O NguyenDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
Frans H J ClaasDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Jamie RossjohnInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Tom C KotsimbosRespiratory Medicine Laboratory, Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Anthony W PurcellInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Nicole A MifsudRespiratory Medicine Laboratory, Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia.
The Alfred Hospital · AUMonash University · AUAustralian Regenerative Medicine Institute · AUCardiff University · GBFiona Stanley Hospital · AULeiden University Medical Center · NLUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T cell receptor (TCR) cross-reactivity, also known as heterologous immunity. Indeed, pathogen-induced TCR cross-reactivity has shown to be a common, robust, and functionally potent mechanism that can trigger a spectrum of human immunopathologies associated with either transplant rejection, drug allergy, and autoimmunity. Here, we report that several virus-specific CD8

Indexed as

CD8-Positive T-LymphocytesCells, CulturedClone CellsCross ReactionsGraft RejectionHLA-B27 AntigenHumansImmunity, HeterologousIsoantigensOrgan TransplantationReceptors, Antigen, T-CellT-Cell Antigen Receptor SpecificityVirus DiseasesVirusesHLA-B27 AntigenIsoantigensReceptors, Antigen, T-CellCMVcross-reactivityEBVHIV-1HLAT cellsTCR

Identifiers

PMID32140156
PMCPMC7042382
OpenAlexW3007929160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.