Evidence map›Paper›PMID 32139897›Full record

ArticleActa pharmacologica Sinica2020

SGK1 mediates the hypotonic protective effect against H

Bao-Yi Chen, Cheng-Cui Huang, Xiao-Fei Lv, Hua-Qing Zheng, Ya-Juan Zhang, Lu Sun, Guan-Lei Wang, Ming-Ming Ma, Yong-Yuan Guan

Open access · bronzeAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Hypotonicity-Induced WNK1 Phosphorylation Prevents HBasic & clinical pharmacology & toxicology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Increased intracellular ClActa pharmacologica Sinica · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Smad2 inhibition ofAtherosclerosis plus · 2021
    Article
  12. Effects of Shenfu Qiangxin Drink on HExperimental and therapeutic medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bao-Yi Chen *Department of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Cheng-Cui Huang *Department of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Xiao-Fei Lv *Department of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Hua-Qing ZhengDepartment of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Ya-Juan ZhangDepartment of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Lu SunDepartment of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Guan-Lei WangDepartment of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Ming-Ming MaDepartment of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China. mamm3@mail.sysu.edu.cn.
Yong-Yuan GuanDepartment of Pharmacology, and Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China. guanyy@mail.sysu.edu.cn.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum- and glucocorticoid-inducible kinease-1 (SGK1) is a serine/threonine kinase regulated by hypotonic stimuli, which is involved in regulation of cell cycle and apoptosis. Our previous study shows that activation of volume-regulated Cl

Indexed as

AnimalsApoptosisBasilar ArteryBcl-2-Like Protein 11Chloride ChannelsDown-RegulationForkhead Box Protein O3Hydrogen PeroxideImmediate-Early ProteinsMaleMyocytes, Smooth MuscleOsmotic PressureProtein Serine-Threonine KinasesRats, Sprague-DawleySerum-Glucocorticoid Regulated KinasesSignal TransductionBcl2l11 protein, ratBcl-2-Like Protein 11Chloride ChannelsForkhead Box Protein O3FOXO3 protein, ratHydrogen PeroxideImmediate-Early ProteinsProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated Kinasesapoptosisbasilar artery smooth muscle cellsBimFOXO3aH2O2hypotonic challengeSGK1volume-regulated Cl− channels

Identifiers

PMID32139897
PMCPMC7470837
OpenAlexW3010061535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.