ArticleScientific reports2020
Fatigue Profiles in Patients with Multiple Sclerosis are Based on Severity of Fatigue and not on Dimensions of Fatigue.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Measuring Fatigue in Multiple Sclerosis: A Rapid Review.The patient · 2025Pooled it
- The effects of fampridine on MS-related fatigue: a systematic review.Frontiers in neurology · 2025Pooled it
- Assessment of muscle fatigue in multiple sclerosis patients in electromyographic examinations.European journal of physical and rehabilitation medicine · 2023Trial
- Disentangling Fatigue Dimensions in Multiple Sclerosis: Differential Associations with Health-Related Quality of Life Outcomes in RRMS.Medical sciences (Basel, Switzerland) · 2026Article
- Similar negative effects of fatigue on physical activity in persons with rheumatoid arthritis and healthy controls: results of a cross-sectional patient-control study.EULAR rheumatology open · 2026Article
- Development of a New Patient-Reported Outcome to Measure Fatigue in Patients with Multiple Sclerosis.Nursing reports (Pavia, Italy) · 2026Article
- Article
- Brain FADE syndrome: the final common pathway of chronic inflammation in neurological disease.Frontiers in immunology · 2024Review
- Validity and Reliability of the Fatigue Severity Scale in a Real-World Interstitial Lung Disease Cohort.American journal of respiratory and critical care medicine · 2023Article
- Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis.Frontiers in physiology · 2023Article
- Observational
- The pathophysiology of motor fatigue and fatigability in multiple sclerosis.Frontiers in neurology · 2022Review
- Subtypes of relapsing-remitting multiple sclerosis identified by network analysis.Frontiers in digital health · 2022Article
- Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis.Medical sciences (Basel, Switzerland) · 2021Article
- Symptom management of patients with multiple sclerosis in primary care: focus on overlooked symptoms.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Article
- Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis.Frontiers in neuroscience · 2021Article
- Bright light therapy as a non-pharmacological treatment option for multiple sclerosis-related fatigue: A randomized sham-controlled trial.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Effects of Nonconsecutive Sessions of Transcranial Direct Current Stimulation and Stationary Cycling on Walking Capacity in Individuals With Multiple Sclerosis.International journal of MS careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue related to Multiple Sclerosis (MS) is considered a multidimensional symptom, manifesting in several dimensions such as physical, cognitive, and psychosocial fatigue. This study investigated in 264 patients with severe primary MS-related fatigue (median MS duration 6.8 years, mean age 48.1 years, 75% women) whether subgroups can be distinguished based on these dimensions. Subsequently, we tested whether MS-related fatigue consists of a single common unidimensional factor. Subscale scores on four self-reported fatigue questionnaires, including the Checklist of Individual Strength, the Modified Fatigue Impact Scale, the Fatigue Severity Scale and the SF36 vitality, were used in a cluster analysis to identify patients with similar fatigue characteristics. Next, all 54 items were included in exploratory factor analysis to test unidimensionality. Study results show that in patients with a treatment indication for primary MS-related fatigue, fatigue profiles are based on severity and not on the various dimensions of fatigue. The three profiles found, suggested one underlying fatigue dimension, but this could not be confirmed. Factor analysis of all 54 items resulted in 8 factors, confirming the multidimensional construct of the included fatigue questionnaires.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.