ArticleScientific reports2020
De novo transcriptome of the diatom Cylindrotheca closterium identifies genes involved in the metabolism of anti-inflammatory compounds.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- How to upgrade stolen organelles into permanent plastids: A comparative transcriptomic perspective.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products.Marine drugs · 2025Review
- Comparative Transcriptomics to Identify RNA Writers and Erasers in Microalgae.International journal of molecular sciences · 2024Article
- Mixotrophic growth of a ubiquitous marine diatom.Science advances · 2024Article
- Screening of Microalgae for Bioactivity with Antiviral, Antibacterial, Anti-Inflammatory and Anti-Cancer Assays.Biology · 2024Article
- Transcriptome Sequencing of the DiatomMarine drugs · 2023Article
- De Novo Transcriptome of the FlagellateBiology · 2022Article
- Bioprospecting of microalgae metabolites against cytokine storm syndrome during COVID-19.Molecular biology reports · 2022Review
- Promising Activities of Marine Natural Products against Hematopoietic Malignancies.Biomedicines · 2021Review
- Unlocking the Health Potential of Microalgae as Sustainable Sources of Bioactive Compounds.International journal of molecular sciences · 2021Review
- Physiological and Molecular Responses to Main Environmental Stressors of Microalgae and Bacteria in Polar Marine Environments.Microorganisms · 2020Review
- Biosynthesis of silver nanoparticles from marine diatomsBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Chemical Defense in Marine Organisms.Marine drugs · 2020Article
- De novo Transcriptome of the Non-saxitoxin ProducingMarine drugs · 2020Article
- In Silico Identification of Type III PKS Chalcone and Stilbene Synthase Homologs in Marine Photosynthetic Organisms.Biology · 2020Article
- PheophorbideMarine drugs · 2020Review
- Monogalactosyldiacylglycerol and Sulfolipid Synthesis in Microalgae.Marine drugs · 2020Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diatoms are the most diverse and abundant group of phytoplankton species and represent a huge reservoir of marine natural products with possible application for human health. Several diatoms are known to have anticancer, anti-inflammatory, antioxidant and anti-microbial properties, but the compounds responsible of these activities are often still unknown. The diatom Cylindrotheca closterium showed anti-inflammatory properties inhibiting TNFα release in human monocytic leukemia cells. In this study, we present the full transcriptome of C. closterium, and used an -omic approach to identify transcripts coding enzymes that can be involved in the synthesis/degradation of anti-inflammatory compounds. This approach allowed to identify phosphatidylinositol-3-phosphatase, phosphatidylinositol 3-kinase catalytic subunit type 3, phosphatidylinositol N-acetylglucosaminyltransferase subunit A, monogalactosyldiacylglycerol synthase and violaxanthin de-epoxidase, which are known to be involved in anti-inflammatory compound metabolism. When C. closterium was cultured in silica-starvation conditions, selected as stress condition to potentially trigger the synthesis of bioactive metabolites, anti-inflammatory activity was lost and expression levels of the analyzed transcripts were reduced. These data suggested that the control culturing condition was the most active. This study used for the first time a transcriptomic-guided approach to identify enzymes involved in anti-inflammatory compound metabolism, directing future discoveries of marine natural products in microalgae.
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