Evidence map›Paper›PMID 32139766›Full record

ArticleScientific reports2020

Cryptochromes modulate E2F family transcription factors.

Alanna B Chan, Anne-Laure Huber, Katja A Lamia

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Development of compounds for targeted degradation of mammalian cryptochrome proteins.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
  13. Article
  14. Cancer, hear my battle CRY.Journal of pineal research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Alanna B ChanDepartment of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Anne-Laure HuberDepartment of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Katja A LamiaDepartment of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. klamia@scripps.edu.
Scripps Research Institute · US

Funding

Impacting Cell Growth through altered circadian proteolysisR01CA211187 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI Katja A Lamia · 2017 to 2026
$4.6M
Regulation of exercise physiology by mammalian cryptochromesR01DK112927 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI LAMIA, KATJA A · 2018 to 2021
$1.7M
NCI NIH HHS R01 CA211187NIDDK NIH HHS R01 DK112927
6 · The paper itself

Abstract

Early 2 factor (E2F) family transcription factors participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and metabolism. Circadian rhythms influence many of these phenomena. Here we find that a mammalian circadian rhythm component, Cryptochrome 2 (CRY2), regulates E2F family members. Furthermore, CRY1 and CRY2 cooperate with the E3 ligase complex SKP-CULLIN-FBXL3 (SCF

Indexed as

Circadian RhythmGene Expression RegulationAnimalsCryptochromesE2F Transcription FactorsMice, KnockoutTranscription FactorsUbiquitin-Protein Ligase ComplexesCry1 protein, mouseCry2 protein, mouseCryptochromesE2F Transcription FactorsTranscription FactorsUbiquitin-Protein Ligase Complexes

Identifiers

PMID32139766
PMCPMC7058038
OpenAlexW3010185184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.