SynthesisNature communications2020
Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 5 pooled it
9.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.Nature communications · 2025Pooled it
- Family history and breast cancer risk for Asian women: a systematic review and meta-analysis.BMC medicine · 2023Pooled it
- Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.Molecular psychiatry · 2023Pooled it
- Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women.Nature communications · 2021Pooled it
- Incorporating European GWAS findings improve polygenic risk prediction accuracy of breast cancer among East Asians.Genetic epidemiology · 2021Pooled it
- Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging.GeroScience · 2026Article
- Improving isoform-level eQTL and integrative genetic analyses of breast cancer risk with long-read RNA transcript assemblies.bioRxiv : the preprint server for biology · 2026Article
- Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci.International journal of cancer · 2025Article
- Genetic and Cellular Architecture of Breast Cancer Risk in Multi-Ancestry Studies of 159,297 Cases and 212,102 Controls.medRxiv : the preprint server for health sciences · 2025Article
- Urea Transporters in Cancer: Emerging Roles and Their Clinical Implications.Biomedicines · 2025Review
- Genetic analyses of eight complex diseases using predicted continuous representations of disease.Cell reports methods · 2025Article
- Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs.National science review · 2025Article
- The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data.American journal of human genetics · 2025Article
- Landscape of TET2 Mutations: From Hematological Malignancies to Solid Tumors.Cancer medicine · 2025Review
- The Impact of microRNA SNPs on Breast Cancer: Potential Biomarkers for Disease Detection.Molecular biotechnology · 2025Review
- Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank.PLoS medicine · 2025Article
- Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions.Nature genetics · 2025Observational
- A proteome-wide association study identifies putative causal proteins for breast cancer risk.British journal of cancer · 2024Article
- Genetic Variants and Haplotype Structures in theHealth science reports · 2024Article
- Breast cancer risk assessment based on susceptibility genes and polygenic risk score in Vietnamese women.BJC reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
62 authors at 20 institutions in 12 countries.
Xiang ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea.
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Sue K ParkDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0001-5002-9707
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4591-1214
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Yaohua YangDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Jiajun ShiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5194-0009
Xingyi GuoDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Bingshan LiDepartment of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-2129-168X
Ran TaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Kristan J AronsonDepartment of Public Health Sciences and Queen's Cancer Research Institute, Queen's University, Kingston, ON, Canada.
Kelvin Y K ChanDepartment of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.
Tsun L ChanHong Kong Hereditary Breast Cancer Family Registry, Hong Kong SAR, China.
Yu-Tang GaoState Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Mikael HartmanDepartment of Surgery, National University Hospital, Singapore, Singapore.
Weang Kee HoDepartment of Applied Mathematics, Faculty of Engineering, University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia.
Hidemi ItoDivision of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID http://orcid.org/0000-0002-8023-4581
Motoki IwasakiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Hiroji IwataDepartment of Breast Oncology, Aichi Cancer Center, Nagoya, Aichi, Japan.
Esther M JohnDepartment of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA.
Yoshio KasugaDepartment of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan.
Ui Soon KhooDepartment of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.
Mi-Kyung KimDivision of Cancer Epidemiology and Management, National Cancer Center, Goyang, Korea.ORCID http://orcid.org/0000-0001-5279-4162
Sun-Young KongNational Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.ORCID http://orcid.org/0000-0003-0620-4058
Allison W KurianDepartments of Health Research and Policy, School of Medicine, Stanford University, California, CA, USA.
Ava KwongHong Kong Hereditary Breast Cancer Family Registry, Hong Kong SAR, China.
Eun-Sook LeeNational Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.ORCID http://orcid.org/0000-0003-1122-8230
Jingmei LiDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-8587-7511
Artitaya LophatananonDivision of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.
Siew-Kee LowRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0003-2386-0698
Shivaani MariapunCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Kenneth MuirDivision of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.ORCID http://orcid.org/0000-0001-6429-988X
Dong-Young NohCancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Boyoung ParkDepartment of Medicine, Hanyang University College of Medicine, Seoul, Korea.
Min-Ho ParkDepartment of Surgery, Chonnam National University Medical School, Seoul, Korea.ORCID http://orcid.org/0000-0003-1504-3815
Chen-Yang ShenCollege of Public Health, China Medical University, Taichong, Taiwan.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea.
John J SpinelliPopulation Oncology, BC Cancer, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-9119-3287
Atsushi TakahashiRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Chiuchen TsengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Shoichiro TsuganeCenter for Public Health Sciences, National Cancer Center, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4105-2774
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yong-Bing XiangState Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Taiki YamajiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Ying ZhengShanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.ORCID http://orcid.org/0000-0001-5764-7268
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6651-7166
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8494-732X
Montserrat García-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1033-2650
Soo-Hwang TeoCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.ORCID http://orcid.org/0000-0002-0444-590X
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Daehee KangDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2444-3247
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Québec City, QC, Canada.ORCID http://orcid.org/0000-0001-6906-3390
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. wei.zheng@vanderbilt.edu.ORCID http://orcid.org/0000-0003-1226-070X
Vanderbilt University Medical Center · USUniversity of Cambridge · GBSeoul National University · KRAichi Cancer Center · JPNational Cancer Center · KRChonnam National University Hwasun Hospital · KRHong Kong Sanatorium and Hospital · HKNational Center for Global Health and Medicine · JPNational University of Singapore · SGRenji Hospital · CNRIKEN Center for Integrative Medical Sciences · JPUniversity of Hong Kong · HKUniversity of Manchester · GBUniversity of Southern California · USCancer Prevention Institute of California · USCancer Research Malaysia · MYCentre hospitalier universitaire de Québec · CAChina Medical University · TWChonnam National University Hospital · KRHanyang University · KR
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MBreast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7MEpidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MShanghai Breast Cancer StudyR01CA064277 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 1996 to 2012
$4.8MCancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7MGenome Sequencing to identify novel genetic factors for breast cancer riskR01CA158473 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2012 to 2016
$4.3MConsortium Study to Identify Breast Cancer Susceptibility LociR01CA148667 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LONG, JIRONG, ZHENG, WEI · 2011 to 2015
$3.3MGenetic Factors for Breast Cancer- A genome Wide StudyR01CA124558 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 2008 to 2012
$3.1MBreast Cancer Survival: Lifestyle and Genetic DeterminantsR01CA118229 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2007 to 2010
$2.9MGenome-wide Copy Number Variation and Breast Cancer RiskR01CA137013 · NCI · VANDERBILT UNIVERSITY · PI LONG, JIRONG · 2009 to 2012
$2.4MSoyfood, Gene Polymorphisms and Endometrial Cancer RiskR01CA092585 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2001 to 2010
$2.3MCancer Research UK 10118Cancer Research UK 16563Cancer Research UK C1287/A10118Cancer Research UK C1287/A16563Cancer Research UK C18281/A19169Department of HealthIntramural NIH HHS Z01 BC011118NCI NIH HHS N01 CN025403NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA092585NCI NIH HHS R01 CA118229NCI NIH HHS R01 CA122756NCI NIH HHS R01 CA124558NCI NIH HHS R01 CA137013NCI NIH HHS R01 CA148667NCI NIH HHS R01 CA158473NCI NIH HHS R37 CA070867NCI NIH HHS U19 CA148065NCI NIH HHS UM1 CA164920NCI NIH HHS UM1 CA182910Wellcome Trust 203477/Z/16/Z
Abstract
Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10
Indexed as
Genetic LociGenetic Predisposition to DiseaseAsian PeopleBreast NeoplasmsFemaleHumansMultifactorial InheritancePolymorphism, Single NucleotideQuantitative Trait LociReceptors, EstrogenRisk FactorsWhite PeopleReceptors, Estrogen
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