ArticleProceedings of the National Academy of Sciences of the United States of America2020
Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
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Who cites it
47 citing papers in PubMed, 92 citations in OpenAlex.
- Hydrogen sulfide in precision medicine: connecting basic science, sensing, and clinical application.Medical gas research · 2026Review
- Extracellular vesicles inherit lactate from aggregated MSCs to alleviate type 1 diabetes mellitus via HJournal of nanobiotechnology · 2026Article
- Reactive sulfur species as emerging immunomodulators: mechanistic insights and therapeutic prospects.Frontiers in immunology · 2026Review
- Effects ofFrontiers in microbiology · 2026Article
- Host-directed therapeutic targets in macrophages and their ligands against mycobacteria tuberculosis.Infection and immunity · 2025Review
- Hydrogen sulfide aggravates neutrophil infiltration, vascular remodeling and elastase-induced abdominal aortic aneurysm in male mice.Communications medicine · 2025Article
- A pH-dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis.Communications biology · 2025Article
- In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer.Nature communications · 2025Article
- Hydrogen Sulfide Promotes TAM-M1 Polarization through Activating IRE-1α Pathway via GRP78 S-Sulfhydrylation to against Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- One health: Subchronic exposure to low ambient hydrogen sulfide increases mortality of influenza A virus infection in mice.Environmental research · 2025Article
- Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment.Cell reports · 2025Article
- Iron-restricted Mycobacterium tuberculosis exports pathogenicity factors packed in extracellular vesicles.PloS one · 2025Article
- Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation.Microbiome · 2024Article
- Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications.Asian journal of pharmaceutical sciences · 2024Review
- Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients Monocyte/lymphocyte bioenergetic signatures post-TB treatment.Frontiers in immunology · 2024Article
- NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis.Nature communications · 2023Article
- Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells.International journal of molecular sciences · 2023Article
- The therapeutic potential for targeting CSE/HVeterinary research · 2023Article
- Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation.bioRxiv : the preprint server for biology · 2023Article
- Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Md Aejazur RahmanAfrica Health Research Institute, 4001 Durban, KwaZulu Natal, South Africa.ORCID 0000-0002-2616-3372
Bridgette M CummingAfrica Health Research Institute, 4001 Durban, KwaZulu Natal, South Africa.ORCID 0000-0001-6977-765X
Kelvin W AddicottAfrica Health Research Institute, 4001 Durban, KwaZulu Natal, South Africa.
Hayden T PaclDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.
Shannon L RussellAfrica Health Research Institute, 4001 Durban, KwaZulu Natal, South Africa.
Kievershen NarganAfrica Health Research Institute, 4001 Durban, KwaZulu Natal, South Africa.
Threnesan NaidooDepartment of Anatomical Pathology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, University of KwaZulu-Natal, 4091 Durban, South Africa.
Pratistadevi K RamdialDepartment of Anatomical Pathology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, University of KwaZulu-Natal, 4091 Durban, South Africa.
John H AdamsonAfrica Health Research Institute, 4001 Durban, KwaZulu Natal, South Africa.
Rui WangDepartment of Biology, York University, Toronto, ON M3J 1P3, Canada.
Adrie J C SteynAfrica Health Research Institute, 4001 Durban, KwaZulu Natal, South Africa; asteyn@uab.edu.ORCID 0000-0001-9177-8827
Africa Health Research Institute · ZANational Health Laboratory Service · ZAUniversity of Alabama at Birmingham · USYork University · CA
Funding
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5MHydrogen Sulfide and Tuberculosis DiseaseR01AI134810 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2018 to 2021
$2.2MInterplay between the Mtb electron transport chain and carbon metabolismR01AI137043 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2019 to 2023
$2.1MHeme oxygenase-1 and the bioenergetic threshold of latent TB and HIV co-infectionR01AI111940 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2015 to 2019
$2.0MMETABOLIC REPROGRAMMING OF T CELL ENERGY METABOLISM IN TUBERCULOSIS AND HIVR61AI138280 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2018 to 2019
$1.0MImmunometabolism of M. tuberculosis/HIV co-infectionR21AI127182 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2016 to 2017
$349kNIAID NIH HHS R01 AI111940NIAID NIH HHS R01 AI134810NIAID NIH HHS R01 AI137043NIAID NIH HHS R21 AI127182NIAID NIH HHS R61 AI138280NIDDK NIH HHS P30 DK079626
Abstract
The ubiquitous gasotransmitter hydrogen sulfide (H
Indexed as
AlkynesAnimalsCarbonCystathionine gamma-LyaseCytokinesEnzyme InhibitorsGlycineGlycolysisHydrogen SulfideLymphocytesMacrophagesMiceMice, Inbred C57BLMice, KnockoutMycobacterium tuberculosisMyeloid CellsAlkynesCarbonCystathionine gamma-LyaseCytokinesEnzyme InhibitorsGlycineHydrogen SulfidepropargylglycineH2Shydrogen sulfidemetabolismpathogenesistuberculosis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.