ArticleProceedings of the National Academy of Sciences of the United States of America2020
Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Astrocyte-Driven Modulation of Whole-Brain Functional Networks and BOLD Signals Revealed by Optogenetic-fMRI.Neuroscience bulletin · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.Nature neuroscience · 2026Article
- Article
- Brainwide blood volume reflects opposing neural populations.bioRxiv : the preprint server for biology · 2025Article
- Timing Is Everything: Temporal Dynamics of BOLD Responses to Naturalistic Features in Movie Watching.bioRxiv : the preprint server for biology · 2025Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.Cell reports · 2025Article
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Sex-specific age-related differences in cerebrospinal fluid clearance assessed by resting-state functional magnetic resonance imaging.NeuroImage · 2024Article
- Identifying the bioimaging features of Alzheimer's disease based on pupillary light response-driven brain-wide fMRI in awake mice.Nature communications · 2024Article
- Decoupling Between Brain Activity and Cerebrospinal Fluid Movement in Neurological Disorders.Journal of magnetic resonance imaging : JMRI · 2024Review
- Cortical Networks Relating to Arousal Are Differentially Coupled to Neural Activity and Hemodynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Group ICA of wide-field calcium imaging data reveals the retrosplenial cortex as a major contributor to cortical activity during anesthesia.Frontiers in cellular neuroscience · 2024Article
- Mapping and comparing fMRI connectivity networks across species.Communications biology · 2023Review
- Resting-state global brain activity affects early β-amyloid accumulation in default mode network.Nature communications · 2023Article
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Authors and funding
8 authors.
Funding
Abstract
Pupillometry, a noninvasive measure of arousal, complements human functional MRI (fMRI) to detect periods of variable cognitive processing and identify networks that relate to particular attentional states. Even under anesthesia, pupil dynamics correlate with brain-state fluctuations, and extended dilations mark the transition to more arousable states. However, cross-scale neuronal activation patterns are seldom linked to brain state-dependent pupil dynamics. Here, we complemented resting-state fMRI in rats with cortical calcium recording (GCaMP-mediated) and pupillometry to tackle the linkage between brain-state changes and neural dynamics across different scales. This multimodal platform allowed us to identify a global brain network that covaried with pupil size, which served to generate an index indicative of the brain-state fluctuation during anesthesia. Besides, a specific correlation pattern was detected in the brainstem, at a location consistent with noradrenergic cell group 5 (A5), which appeared to be dependent on the coupling between different frequencies of cortical activity, possibly further indicating particular brain-state dynamics. The multimodal fMRI combining concurrent calcium recordings and pupillometry enables tracking brain state-dependent pupil dynamics and identifying unique cross-scale neuronal dynamic patterns under anesthesia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.