ArticleDiabetes2020
Role of Proinsulin Self-Association in Mutant
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Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
What it found
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- Coordinated expression and assembly of BiP, p58Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural Communication Between C-Peptide and Insulin Within the Proinsulin Molecule.International journal of molecular sciences · 2026Article
- Stress-driven remodeling of antigen presentation and chemokine signaling in pancreatic β-cells: implications for type 1 diabetes.Frontiers in immunology · 2026Review
- Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis.The Journal of clinical investigation · 2025Article
- Quantification of Folded and Misfolded Proinsulin Forms Using Nonreducing SDS-PAGE and Proinsulin-Specific Immunoblotting.Bio-protocol · 2025Article
- Protein aggregates and biomolecular condensates: implications for human health and disease.Frontiers in molecular biosciences · 2025Review
- Exploring proinsulin proteostasis: insights into beta cell health and diabetes.Frontiers in molecular biosciences · 2025Review
- Synthetic studies of the mutant proinsulin syndrome demonstrate correlation between folding efficiency and age of diabetes onset.International journal of peptide research and therapeutics · 2025Article
- Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.Protein science : a publication of the Protein Society · 2024Article
- Pancreatic beta cell ER export in health and diabetes.Frontiers in endocrinology · 2023Review
- Protein quality control and aggregation in the endoplasmic reticulum: From basic to bedside.Frontiers in cell and developmental biology · 2023Review
- IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Determinants of IGF-II influencing stability, receptor binding and activation.Scientific reports · 2022Article
- Diabetes-Associated Mutations in Proinsulin Provide a "Molecular Rheostat" of Nascent Foldability.Current diabetes reports · 2022Review
- Novel Pathogenic De Novo INS p.T97P Variant Presenting With Severe Neonatal DKA.Endocrinology · 2022Article
- Review
- Article
- Distinct states of proinsulin misfolding in MIDY.Cellular and molecular life sciences : CMLS · 2021Article
- Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.The Journal of clinical investigation · 2021Review
- Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum.Progress in molecular and subcellular biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 2 countries.
Jinhong SunDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI.
Yi XiongDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI.
Xin LiDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Leena HaatajaDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI.
Wei ChenDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI.
Saiful A MirDevelopment, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.
Li LvDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Rachel MadleyDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI.
Dennis LarkinDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI.
Arfah AnjumDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI.
Balamurugan DhayalanDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN.
Nischay RegeDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH.
Nalinda P WickramasingheDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH.
Michael A WeissDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN.
Pamela Itkin-AnsariDevelopment, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.
Randal J KaufmanDegenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.
David A OstrovDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL.
Peter ArvanDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI mingliu@tmu.edu.cn parvan@umich.edu.ORCID 0000-0002-4007-8799
Ming LiuDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI mingliu@tmu.edu.cn parvan@umich.edu.ORCID 0000-0003-2665-4072
University of Michigan · USSanford Burnham Prebys Medical Discovery Institute · USCase Western Reserve University · USIndiana University School of MedicineTianjin Medical University General Hospital · CNUniversity of Florida · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MThe Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLIAM H HERMAN · 2013 to 2026
$24.3MIntegrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8MProinsulin Trafficking for Insulin BiosynthesisR01DK048280 · NIDDK · YESHIVA UNIVERSITY · PI ARVAN, PETER · 1994 to 2024
$10.5MNon-Standard Protein Design in Molecular Endocrinology: Insulin and GlucagonR01DK040949 · NIDDK · UNIVERSITY OF CHICAGO · PI CHERRINGTON, ALAN D, GEORGIADIS, MILLIE M · 1989 to 2024
$8.4MSecretory Pathway Protein Degradation Maintains Insulin Biogenesis + SecretionR01DK111174 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARVAN, PETER, QI, LING · 2016 to 2024
$5.5MModifiers of Proinsulin Influence T2D SusceptibilityR24DK110973 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ARVAN, PETER, ITKIN-ANSARI, PAMELA ROSE · 2016 to 2019
$4.1MDevelopment and characterization of ultra-stable insulin analogs for novel therapeutic useF30DK112644 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI REGE, NISCHAY KIRAN · 2016 to 2020
$179kNIDDK NIH HHS F30 DK112644NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK040949NIDDK NIH HHS R01 DK048280NIDDK NIH HHS R01 DK111174NIDDK NIH HHS R24 DK110973NIDDK NIH HHS U24 DK098085NIDDK NIH HHS UC4 DK098085NIGMS NIH HHS T32 GM007250
Abstract
Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin (PI) in the endoplasmic reticulum (ER) drive the molecular pathogenesis of mutant
Indexed as
AnimalsCell LineHumansInsulinIslets of LangerhansMiceModels, MolecularMutationProinsulinProtein ConformationInsulinProinsulin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.