ArticleDiabetes2020
MG53 Does Not Manifest the Development of Diabetes in
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Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 48 citations in OpenAlex.
- MG53, a Regenerative Myokine Linking Skeletal Muscle to Cardiac Repair.Biomolecules · 2026Review
- MG53 protects against intestinal inflammation by inhibiting NLRP3 inflammasome activation.Frontiers in pharmacology · 2026Article
- MuRF1 Partners With TRIM72 to Impair Insulin Signaling in Skeletal Muscle Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- The Relationship Between Serum MG53 Levels and the Presence of Metabolic Syndrome and Its Components.Medicina (Kaunas, Lithuania) · 2025Article
- Mitsugumin 53 Inhibits Angiogenesis Through Regulating Focal Adhesion Turnover and Tip Cell Formation.Journal of cellular and molecular medicine · 2025Article
- Recombinant human mitsugumin 53: a potential therapeutic agent for multiple diseases.Frontiers in pharmacology · 2025Review
- MG53 mitigates warm ischemic lung injury in a murine model of transplantation.The Journal of thoracic and cardiovascular surgery · 2024Article
- Mitsugumin 53 mitigation of ischemia-reperfusion injury in a mouse model.The Journal of thoracic and cardiovascular surgery · 2024Article
- MG53/TRIM72: multi-organ repair protein and beyond.Frontiers in physiology · 2024Review
- Molecular mechanisms of metabolic dysregulation in diabetic cardiomyopathy.Frontiers in cardiovascular medicine · 2024Review
- MG53's non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues.Frontiers in endocrinology · 2024Article
- Activation of MG53 Enhances Cell Survival and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Injured Hearts.Stem cell reviews and reports · 2023Article
- MG53: A potential therapeutic target for kidney disease.Pharmacology research & perspectives · 2023Review
- Is MG53 a potential therapeutic target for cancer?Frontiers in endocrinology · 2023Review
- Remote Ischemic Pre-Conditioning (RIPC).Methods in molecular biology (Clifton, N.J.) · 2023Article
- Association of MG53 with presence of type 2 diabetes mellitus, glycemic control, and diabetic complications.PloS one · 2023Article
- Prohibiting MG53 Phosphorylation Optimizes its Therapeutic Potential in Diabetes.Circulation research · 2022Article
- Blocking MG53Circulation research · 2022Article
- Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development.Bioactive materials · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 2 countries.
Qiang WangDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Zehua BianDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Qiwei JiangDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Xiaoliang WangDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Xinyu ZhouDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Ki Ho ParkDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Willa HsuehDiabetes and Metabolism Research Center, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.ORCID 0000-0002-7321-4398
Bryan A WhitsonDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Erin HaggardDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Haichang LiDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Ken ChenDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Chuanxi CaiDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Tao TanDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH jianjie.ma@osumc.edu hua.zhu@osumc.edu ttan@trim-edicine.com.
Hua ZhuDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH jianjie.ma@osumc.edu hua.zhu@osumc.edu ttan@trim-edicine.com.
Jianjie MaDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH jianjie.ma@osumc.edu hua.zhu@osumc.edu ttan@trim-edicine.com.ORCID 0000-0003-3865-6112
The Ohio State University Wexner Medical Center · USArmy Medical University · CN
Funding
MG53-Mediated Membrane Repair in Muscle Physiology and DiseaseR01AR061385 · NIAMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI LIN, PEI-HUI · 2011 to 2020
$3.8MPreservation and Rescue of The Lung Donor Allograft for TransplantationR01HL143000 · NHLBI · OHIO STATE UNIVERSITY · PI WHITSON, BRYAN A · 2018 to 2022
$3.4MTargeting cell membrane repair for treatment of acute kidney injuryR01DK106394 · NIDDK · OHIO STATE UNIVERSITY · PI LIN, PEI-HUI, ROVIN, BRAD H · 2016 to 2020
$2.5MHydrogel encapsulation of a tissue repair protein to treat chronic woundsR01AG056919 · NIA · OHIO STATE UNIVERSITY · PI GUAN, JIANJUN, LI, HAICHANG · 2017 to 2021
$2.4MImpact of the Adipose Tissue Microenvironment on AtherosclerosisR01HL135622 · NHLBI · OHIO STATE UNIVERSITY · PI HSUEH, WILLA A · 2018 to 2021
$2.1MProtein therapeutic to facilitate healing of chronic wounds.R44GM123887 · NIGMS · TRIM-EDICINE, INC. · PI TAN, TAO · 2019 to 2021
$1.8MMyokine function of MG53 in muscle injury-repair and regenerationR01AR070752 · NIAMS · OHIO STATE UNIVERSITY · PI HAN, RENZHI · 2017 to 2021
$1.7MRegulation of Mitsugumin 29 expression in muscle physiology and diseasesR01AR067766 · NIAMS · OHIO STATE UNIVERSITY · PI ZHU, HUA · 2016 to 2020
$1.6MPreservation of Limbal Stem Cell Function in Corneal InjuryR01EY030621 · NEI · OHIO STATE UNIVERSITY · PI CHANDLER, HEATHER, ZHU, HUA · 2019 to 2022
$1.6MNEI NIH HHS R01 EY030621NHLBI NIH HHS R01 HL135622NHLBI NIH HHS R01 HL143000NIAMS NIH HHS R01 AR061385NIAMS NIH HHS R01 AR067766NIAMS NIH HHS R01 AR070752NIA NIH HHS R01 AG056919NIDDK NIH HHS R01 DK106394NIGMS NIH HHS R44 GM123887
Abstract
MG53 is a member of the TRIM protein family that is predominantly expressed in striated muscles and participates in cell membrane repair. Controversy exists regarding MG53's role in insulin signaling and manifestation of diabetes. We generated
Indexed as
Blood GlucoseInsulin ResistanceAnimalsAntibodies, MonoclonalBurns, ChemicalCorneal InjuriesGene Expression RegulationGlucoseHumansMaleMembrane ProteinsMiceMice, Inbred NODMice, KnockoutRabbitsRecombinant ProteinsAntibodies, MonoclonalBlood GlucoseGlucoseMembrane ProteinsMG53 protein, mouseRecombinant ProteinsTRIM72 protein, humanTripartite Motif Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.