ArticleBMJ open2020
Impact of preterm birth on brain development and long-term outcome: protocol for a cohort study in Scotland.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Protein epigenetic scores derived in neonatal saliva as biomarkers of childhood cognition.Molecular psychiatry · 2026Article
- From microbes to milestones: Gut bacterial abundances and functional pathways associate with neurodevelopment following preterm birth.Gut microbiology · 2026Article
- Neonatal amygdala microstructure and structural connectivity are associated with autistic traits at 2 years of age.Developmental cognitive neuroscience · 2026Article
- Effects of prematurity and socio-economic status on early life language exposure: A video coding study.The British journal of developmental psychology · 2026Article
- Neural and behavioural correlates of theory of mind reasoning in five-year-old children born preterm.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- A multi-level analysis of motor and behavioural dynamics in 9-month-old preterm and term-born infants during changing emotional and interactive contexts.Scientific reports · 2025Article
- Association of maternal metal exposure and psychological status with adverse pregnancy outcomes: a nested case-control study.Frontiers in public health · 2025Article
- Parental report of language, attention and executive functions at two years: correlational structure of measures and applications to prematurity.Wellcome open research · 2025Article
- Sex differences in delivery and neonatal characteristics of new-borns from the "MAMI-MED" cohort.Frontiers in public health · 2025Article
- Brain 3T magnetic resonance imaging in neonates: features and incidental findings from a research cohort enriched for preterm birth.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- The neonatal gut microbiota: A role in the encephalopathy of prematurity.Cell reports. Medicine · 2024Article
- Article
- Epigenetic scores derived in saliva are associated with gestational age at birth.Clinical epigenetics · 2024Article
- Nasal cathelicidin is expressed in early life and is increased during mild, but not severe respiratory syncytial virus infection.Scientific reports · 2024Article
- Feature similarity gradients detect alterations in the neonatal cortex associated with preterm birth.Human brain mapping · 2024Article
- An unexpected ferromagnetic foreign body in a paediatric research participant undergoing 3T MRI.BMJ case reports · 2024Article
- Early biomarkers of neurodevelopmental disorders in preterm infants: protocol for a longitudinal cohort study.BMJ open · 2023Article
- Association of Preterm Birth and Socioeconomic Status With Neonatal Brain Structure.JAMA network open · 2023Article
- Characterisation of the neonatal brain using myelin-sensitive magnetisation transfer imaging.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Language function following preterm birth: prediction using machine learning.Pediatric research · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
introductionPreterm birth is closely associated with altered brain development and is a leading cause of neurodevelopmental, cognitive and behavioural impairments across the life course. We aimed to investigate neuroanatomic variation and adverse outcomes associated with preterm birth by studying a cohort of preterm infants and controls born at term using brain MRI linked to biosamples and clinical, environmental and neuropsychological data. METHODS AND ANALYSIS: Theirworld Edinburgh Birth Cohort is a prospective longitudinal cohort study at the University of Edinburgh. We plan to recruit 300 infants born at <33 weeks of gestational age (GA) and 100 healthy control infants born after 37 weeks of GA. Multiple domains are assessed: maternal and infant clinical and demographic information; placental histology; immunoregulatory and trophic proteins in umbilical cord and neonatal blood; brain macrostructure and microstructure from structural and diffusion MRI (dMRI); DNA methylation; hypothalamic-pituitary-adrenal axis activity; social cognition, attention and processing speed from eye tracking during infancy and childhood; neurodevelopment; gut and respiratory microbiota; susceptibility to viral infections; and participant experience. Main analyses include creation of novel methods for extracting information from neonatal structural and dMRI, regression analyses of predictors of brain maldevelopment and neurocognitive outcome associated with preterm birth, and determination of the quantitative predictive performance of MRI and other early life factors for childhood outcome. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the National Research Ethics Service (NRES), South East Scotland Research Ethics Committee (NRES numbers 11/55/0061 and 13/SS/0143 (phase I) and 16/SS/0154 (phase II)), and NHS Lothian Research and Development (2016/0255). Results are disseminated through open access journals, scientific meetings, social media, newsletters anda study website (www.tebc.ed.ac.uk), and we engage with the University of Edinburgh public relations and media office to ensure maximum publicity and benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.