Evidence map›Paper›PMID 32139434›Full record

ReviewHaematologica2020

Glanzmann thrombasthenia: genetic basis and clinical correlates.

Juliana Perez Botero, Kristy Lee, Brian R Branchford, Paul F Bray, Kathleen Freson, Michele P Lambert, Minjie Luo, Shruthi Mohan, Justyne E Ross, Wolfgang Bergmeier and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 140 citations in OpenAlex.

  1. Article
  2. Observational
  3. The co-inheritance of twoHaematologica · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. European Management of Glanzmann's Thrombasthenia: A Survey of Current Clinical Practice.Haemophilia : the official journal of the World Federation of Hemophilia · 2025
    Article
  10. Review
  11. Observational
  12. Article
  13. Article
  14. Obstetric and Gynaecological Challenges and Outcomes in Women and Girls With Glanzmann's Thrombasthenia.Haemophilia : the official journal of the World Federation of Hemophilia · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Observational
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Juliana Perez BoteroVersiti and Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Kristy LeeDepartment of Genetics, University of North Carolina at Chapel Hill, NC, USA.
Brian R BranchfordUniversity of Colorado School of Medicine, Department of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplant, Aurora, CO, USA.
Paul F BrayMolecular Medicine Program, Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Utah, Salt Lake City, UT, USA.
Kathleen FresonCenter for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.
Michele P LambertThe Children's Hospital of Philadelphia and Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, USA.
Minjie LuoDepartment of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA, USA.
Shruthi MohanDepartment of Genetics, University of North Carolina at Chapel Hill, NC, USA.
Justyne E RossDepartment of Genetics, University of North Carolina at Chapel Hill, NC, USA.
Wolfgang BergmeierDepartment of Biochemistry and Biophysics and UNC Blood Research Center, University of North Carolina at Chapel Hill, NC, USA.
Jorge Di PaolaDivision of Pediatric Hematology Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, MO, USA dipaolaj@wustl.edu.
ClinGen Platelet Disorder Variant Curation Expert Panel
University of North Carolina at Chapel Hill · USChildren's Hospital of Philadelphia · USKU Leuven · BEMedical College of Wisconsin · USUniversity of Colorado Denver · USUniversity of Utah · USWashington University in St. Louis · US

Funding

The Clinical Genome Resource - Expert Curation and EHR IntegrationU41HG009650 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BERG, JONATHAN S · 2017 to 2020
$13.3M
In vivo studies of megakaryocyte microRNAs regulating platelet number and integrin activationR01HL141424 · NHLBI · UNIVERSITY OF UTAH · PI BRAY, PAUL F. · 2018 to 2021
$2.5M
NHGRI NIH HHS U41 HG009650NHLBI NIH HHS R01 HL141424
6 · The paper itself

Abstract

Glanzmann thrombasthenia (GT) is an autosomal recessive disorder of platelet aggregation caused by quantitative or qualitative defects in integrins αIIb and β3. These integrins are encoded by the

Indexed as

ThrombastheniaBlood PlateletsHumansIntegrin beta3Platelet AggregationPlatelet Function TestsPlatelet Glycoprotein GPIIb-IIIa ComplexIntegrin beta3Platelet Glycoprotein GPIIb-IIIa Complex

Identifiers

PMID32139434
PMCPMC7109743
OpenAlexW3009338033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.