Evidence map›Paper›PMID 32139421›Full record

ArticleGenes & development2020

Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.

Jennifer C Harr, Christoph D Schmid, Celia Muñoz-Jiménez, Raquel Romero-Bueno, Véronique Kalck, Adriana Gonzalez-Sandoval, Michael H Hauer, Jan Padeken, Peter Askjaer, Anna Mattout and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
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  4. The role of inner nuclear membrane protein emerin in myogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
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  18. The Nuclear Lamina.Cold Spring Harbor perspectives in biology · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jennifer C HarrFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Christoph D SchmidFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Celia Muñoz-JiménezAndalusian Center for Developmental Biology (CABD), Consejo Superior de Investigaciones Científicas, Universidad Pablo de Olavide, Seville 41013, Spain.
Raquel Romero-BuenoAndalusian Center for Developmental Biology (CABD), Consejo Superior de Investigaciones Científicas, Universidad Pablo de Olavide, Seville 41013, Spain.
Véronique KalckFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Adriana Gonzalez-SandovalFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Michael H HauerFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Jan PadekenFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Peter AskjaerAndalusian Center for Developmental Biology (CABD), Consejo Superior de Investigaciones Científicas, Universidad Pablo de Olavide, Seville 41013, Spain.
Anna MattoutFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Susan M GasserFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Friedrich Miescher Institute · CHUniversidad Pablo de Olavide · ES

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mutations in the nuclear structural protein lamin A produce rare, tissue-specific diseases called laminopathies. The introduction of a human Emery-Dreifuss muscular dystrophy (EDMD)-inducing mutation into the

Indexed as

Gene DeletionAnimalsBinding SitesCaenorhabditis elegansCaenorhabditis elegans ProteinsCell NucleusChromatinChromosomal Proteins, Non-HistoneDisease Models, AnimalGenome, HelminthLamininMusclesMuscular Dystrophy, Emery-DreifussMutationProtein Structure, TertiarySarcomeresCaenorhabditis elegans ProteinsCEC-4 protein, C elegansChromatinChromosomal Proteins, Non-HistoneLamininLMN-1 protein, C elegansCEC-4C. elegansEDMDLADslamin Alaminopathynuclear organization

Identifiers

PMID32139421
PMCPMC7111258
OpenAlexW3010196267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.