Evidence map›Paper›PMID 32139154›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2020

Gut microbiota, endotoxemia, inflammation, and oxidative stress in patients with heart failure, left ventricular assist device, and transplant.

Melana Yuzefpolskaya, Bruno Bohn, Mojdeh Nasiri, Amelia M Zuver, Drew D Onat, Eugene A Royzman, Joseph Nwokocha, Melissa Mabasa, Alberto Pinsino, Danielle Brunjes and 15 more

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05655910 narecruitingnot on this mapstarted 2022, after this paper: background citation

Enhanced Nutritional Optimization in LVAD (ENOL) Trial

TypeinterventionalSponsorColumbia UniversityRan2022 to 2027Enrolled50ConditionsHeart Failure, Gut Microbiome, Nutritional DeficiencyArmsEnsure Surgery Immunonutrition shake
NCT07490054 phase1recruitingnot on this mapstarted 2025, after this paper: background citation

An Open-Label, Pilot Clinical Trial To Test The Safety And Feasibility Of Intestinal Microbiota Transplantation In Patients With Chronic Heart Failure

TypeinterventionalSponsorMelana Yuzefpolskaya, MDRan2025 to 2027Enrolled40ConditionsChronic Heart FailureArmsMTP-101-C encapsulated Microbiota, Vancomycin, Neomycin
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Review: the role of GSDMD in sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. The gut as a central hub for multi-organ crosstalk in aging.Cellular and molecular life sciences : CMLS · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Gut microbiota's role in heart failure.Heart failure reviews · 2025
    Review
  17. Review
  18. Review
  19. Article
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 1 country.

Melana YuzefpolskayaDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Bruno BohnDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Mojdeh NasiriDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Amelia M ZuverDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Drew D OnatDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Eugene A RoyzmanDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Joseph NwokochaDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Melissa MabasaDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Alberto PinsinoDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Danielle BrunjesDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Antonia GaudigDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Autumn ClemonsDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Pauline TrinhDepartment of Environmental and Occupational Health Sciences, University of Washington, School of Public Health, Seattle, Washington.
Stephania StumpDepartment of Medicine, Division of Infectious Diseases and Microbiome and Pathogen Genomics Core, New York Presbyterian Hospital, Columbia University, New York City, New York.
Marla J GiddinsDepartment of Medicine, Division of Infectious Diseases and Microbiome and Pathogen Genomics Core, New York Presbyterian Hospital, Columbia University, New York City, New York.
Veli K TopkaraDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
A Reshad GaranDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Koji TakedaDivision of Cardiothoracic Surgery, Department of Surgery, New York Presbyterian Hospital, Columbia University, New York City, New York.
Hiroo TakayamaDivision of Cardiothoracic Surgery, Department of Surgery, New York Presbyterian Hospital, Columbia University, New York City, New York.
Yoshifumi NakaDivision of Cardiothoracic Surgery, Department of Surgery, New York Presbyterian Hospital, Columbia University, New York City, New York.
Maryjane A FarrDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Renu NandakumarBiomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, New York Presbyterian Hospital, Columbia University, New York City, New York.
Anne-Catrin UhlemannDepartment of Medicine, Division of Infectious Diseases and Microbiome and Pathogen Genomics Core, New York Presbyterian Hospital, Columbia University, New York City, New York.
Paolo C ColomboDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York City, New York.
Ryan T DemmerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota; Division of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York. Electronic address: demm0009@umn.edu.
NewYork–Presbyterian Hospital · USUniversity of Minnesota · USUniversity of Washington · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Biostatistics, Epidemiologic & Bioinformatic Training in Environmental HealthT32ES015459 · NIEHS · UNIVERSITY OF WASHINGTON · PI June T. Spector · 2009 to 2026
$10.6M
The Subgingival Microbiome and Impaired Glucose RegulationR01DK102932 · NIDDK · UNIVERSITY OF MINNESOTA · PI DEMMER, RYAN T. · 2015 to 2019
$3.1M
NCATS NIH HHS UL1 TR001873NIDDK NIH HHS R01 DK102932NIEHS NIH HHS T32 ES015459
6 · The paper itself

Abstract

backgroundGut microbial imbalance may contribute to endotoxemia, inflammation, and oxidative stress in heart failure (HF). Changes occurring in the intestinal microbiota and inflammatory/oxidative milieu during HF progression and following left ventricular assist device (LVAD) or heart transplantation (HT) are unknown. We aimed to investigate variation in gut microbiota and circulating biomarkers of endotoxemia, inflammation, and oxidative stress in patients with HF (New York Heart Association, Class I-IV), LVAD, and HT.

methodsWe enrolled 452 patients. Biomarkers of endotoxemia (lipopolysaccharide and soluble [sCD14]), inflammation (C-reactive protein, interleukin-6, tumor necrosis factor-α, and endothelin-1 adiponectin), and oxidative stress (isoprostane) were measured in 644 blood samples. A total of 304 stool samples were analyzed using 16S rRNA sequencing.

resultsGut microbial community measures of alpha diversity were progressively lower across worsening HF class and were similarly reduced in patients with LVAD and HT (p < 0.05). Inflammation and oxidative stress were elevated in patients with Class IV HF vs all other groups (all p < 0.05). Lipopolysaccharide was elevated in patients with Class IV HF (vs Class I-III) as well as in patients with LVAD and HT (p < 0.05). sCD14 was elevated in patients with Class IV HF and LVAD (vs Class I-III, p < 0.05) but not in patients with HT.

conclusionsReduced gut microbial diversity and increased endotoxemia, inflammation, and oxidative stress are present in patients with Class IV HF. Inflammation and oxidative stress are lower among patients with LVAD and HT relative to patients with Class IV HF, whereas reduced gut diversity and endotoxemia persist in LVAD and HT.

Indexed as

Heart-Assist DevicesHeart TransplantationEndotoxemiaFemaleFollow-Up StudiesGastrointestinal MicrobiomeHeart FailureHeart VentriclesHumansInflammationMaleMiddle AgedRetrospective StudiesVentricular Function, Leftgut dysbiosisheart failureheart transplantationinflammationleft ventricular assist deviceoxidative stress

Identifiers

PMID32139154
PMCPMC7423693
OpenAlexW3006437011

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.