Evidence map›Paper›PMID 32138939›Full record

ArticleBehavior therapy2020

The Early Childhood Irritability-Related Impairment Interview (E-CRI): A Novel Method for Assessing Young Children's Developmentally Impairing Irritability.

Lauren S Wakschlag, Sheila Krogh-Jespersen, Ryne Estabrook, Christina O Hlutkowsky, Erica L Anderson, James Burns, Margaret J Briggs-Gowan, Amélie Petitclerc, Susan B Perlman

Erratum issuedAbstract read
In one paragraph

Article in Behavior therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Roads Diverged: Developmental Trajectories of Irritability From Toddlerhood Through Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Toward a Developmental Nosology for Disruptive Mood Dysregulation Disorder in Early Childhood.Journal of the American Academy of Child and Adolescent Psychiatry · 2021
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lauren S WakschlagNorthwestern University Feinberg School of Medicine and Institute for Innovations in Developmental Sciences. Electronic address: lauriew@northwestern.edu.
Sheila Krogh-JespersenNorthwestern University Feinberg School of Medicine and Institute for Innovations in Developmental Sciences.
Ryne EstabrookUniversity of Illinois at Chicago.
Christina O HlutkowskyWashington University.
Erica L AndersonInstitute for Innovations in Developmental Sciences.
James BurnsNorthwestern University.
Margaret J Briggs-GowanUniversity of Connecticut School of Medicine.
Amélie PetitclercNorthwestern University and Institute for Innovations in Developmental Sciences.
Susan B PerlmanWashington University School of Medicine.

Funding

Generating an Earlier Science of When to Worry: A Neurodevelopmental, Transactional Approach to Characterizing Irritability Patterns Beginning in InfancyR01MH107652 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2016 to 2021
$4.0M
From Irritability to Impairment: How Neurodevelopment of Executive Function and Parent-Child Neural Synchrony Influence the Transition from Normal to Abnormal FunctioningR01MH107540 · NIMH · WASHINGTON UNIVERSITY · PI PERLMAN, SUSAN B · 2015 to 2019
$3.1M
NIMH NIH HHS R01 MH107540NIMH NIH HHS R01 MH107652
6 · The paper itself

Abstract

Irritability is a substrate of more than one dozen clinical syndromes. Thus, identifying when it is atypical and interfering with functioning is crucial to the prevention of mental disorder in the earliest phase of the clinical sequence. Advances in developmentally based measurement of irritability have enabled differentiation of normative irritable mood and tantrums from indicators of concern, beginning in infancy. However, developmentally sensitive assessments of irritability-related impairment are lacking. We introduce the Early Childhood Irritability-Related Impairment Interview (E-CRI), which assesses impairment associated with irritable mood and tantrums across contexts. Reliability and validity are established across two independent samples varied by developmental period: the Emotional Growth preschool sample (EmoGrow; N = 151, M = 4.82 years) and the When to Worry infant/toddler sample (W2W; N = 330, M = 14 months). We generated a well-fitting two-factor E-CRI model, with tantrum- and irritable mood-related impairment factors. The E-CRI exhibited good interrater, test-retest, and longitudinal reliability. Construct and clinical validity were also demonstrated. In both samples, E-CRI factors showed association to internalizing and externalizing problems, and to caregiver-reported concern in W2W. Tantrum-related impairment demonstrated stronger and more consistent explanatory value across outcomes, while mood-related impairment added explanatory utility for internalizing problems. The E-CRI also showed incremental utility beyond variance explained by the Family Life Impairment Scale (FLIS) survey indicator of developmental impairment. The E-CRI holds promise as an indicator of impairment to inform identification of typical versus atypical patterns reflecting early emerging irritability-related syndromes in the initial phase of the clinical sequence.

Indexed as

Irritable MoodAggressionChild Behavior DisordersChild, PreschoolDefense MechanismsFemaleHumansInterview, PsychologicalMaleReproducibility of ResultsResearch Designdevelopmental psychopathologyearly childhoodirritability

Identifiers

PMID32138939
PMCPMC10127521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.