Evidence map›Paper›PMID 32138788›Full record

ArticleJournal of experimental & clinical cancer research : CR2020

From single gene analysis to single cell profiling: a new era for precision medicine.

Maria Teresa Di Martino, Stefania Meschini, Katia Scotlandi, Chiara Riganti, Enrico De Smaele, Francesca Zazzeroni, Massimo Donadelli, Carlo Leonetti, Michele Caraglia

Open access · goldAbstract readConference Proceedings
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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  7. Association of theJournal of psychopharmacology (Oxford, England) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 2 countries.

Maria Teresa Di MartinoDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Graecia", Catanzaro, Italy. teresadm@unicz.it.
Stefania MeschiniNational Center for Drug Research and Evaluation, National Institute of Health, Rome, Italy.
Katia ScotlandiIRCCS Istituto Ortopedico Rizzoli, Experimental Oncology Lab, Bologna, Italy.
Chiara RigantiDepartment of Oncology, University of Torino, Turin, Italy.
Enrico De SmaeleDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Francesca ZazzeroniDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Massimo DonadelliDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy.
Carlo LeonettiUOSD SAFU, IRCCS-Regina Elena National Cancer Institute, Rome, Italy. carlo.leonetti@ifo.gov.it.ORCID http://orcid.org/0000-0002-3526-7827
Michele CaragliaDepartment of Precision Medicine, University of Campania "L. Vanvitelli", Naples and Biogem Scarl, Institute of Genetic Research, Laboratory of Precision and Molecular Oncology, Ariano Irpino, Italy.
Biogem · ITIstituto Ortopedico Rizzoli · ITMagna Graecia University · ITNational Cancer Institute · MYSapienza University of Rome · ITUniversity of L'Aquila · ITUniversity of Turin · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders, as well as an increased understanding of basic mechanisms that regulate human disease. Recent technological advances have enabled the analyses of alterations in gene-based structure or function in a comprehensive, high-throughput fashion showing that each tumor type typically exhibits distinct constellations of genetic alterations targeting one or more key cellular pathways that regulate cell growth and proliferation, evasion of the immune system, and other aspects of cancer behavior. These advances have important implications for future research and clinical practice in areas as molecular diagnostics, the implementation of gene or pathway-directed targeted therapy, and the use of such information to drive drug discovery. The 1st international and 32nd Annual Conference of Italian Association of Cell Cultures (AICC) conference wanted to offer the opportunity to match technological solutions and clinical needs in the era of precision medicine.

Indexed as

Early DiagnosisGenetic Predisposition to DiseaseGenetic TestingHumansItalyPrecision MedicineSingle-Cell AnalysisBiomarkersFunctional omicsPersonalized therapySingle-cellTumor profiling

Identifiers

PMID32138788
PMCPMC7059661
OpenAlexW3012236699

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.