Evidence map›Paper›PMID 32138784›Full record

Trial reportBMC ophthalmology2020

Effect of dexmedetomidine on prevention of postoperative nausea and vomiting in pediatric strabismus surgery: a randomized controlled study.

Shuangshuang Li, Tingjie Liu, Junming Xia, Jie Jia, Wenxian Li

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05233683 (Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05233683 phase3unknown statusnot on this mapstarted 2022, after this paper: background citation

Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children

TypeinterventionalSponsorKing Saud UniversityRan2022 to 2023Enrolled120ConditionsAnesthesia, Anesthesia, Local, Analgesia, Pediatric ALLArmsCaudal block, Dorsal penile nerve block plus ring block, Circumcision with Plastibell, Conventional Dissection Method
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. The Oculocardiac Reflex: A Review.Clinical ophthalmology (Auckland, N.Z.) · 2021
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shuangshuang LiDepartment of Anesthesiology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Tingjie LiuDepartment of Anesthesiology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Junming XiaDepartment of Anesthesiology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Jie JiaDepartment of Anesthesiology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China. jiajie@eentanesthesia.com.
Wenxian LiDepartment of Anesthesiology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China. liwenxian@eentanesthesia.com.
Eye & ENT Hospital of Fudan University · CN

Funding

National Natural Science Foundation of China 81671059Scientific Research Project of Shanghai Minhang District Health and Family Planning Commission 2018MW59
6 · The paper itself

Abstract

backgroundPostoperative nausea and vomiting (PONV) are common side-effects following strabismus surgery. The present study aimed to compare the effects of different doses of dexmedetomidine (DEX) on PONV incidence in pediatric patients undergoing strabismus surgery.

methodsIn this prospective randomized double-blinded study, 126 pediatric patients undergoing strabismus surgery were randomized into one of three groups: Placebo group, normal saline; DEX1 group, 0.3 μg/kg dexmedetomidine, and DEX2 group, 0.5 μg/kg dexmedetomidine. Oculocardiac reflex (OCR) events were recorded during surgery. PONV or postoperative vomiting (POV) was recorded for 24 h in the ward. Pediatric anesthesia emergence delirium (PAED) scale and emergence agitation (EA) scale were recorded in the recovery room.

resultsIntraoperative OCR was significantly reduced in DEX2 group (42%) as compared to that of Placebo group (68%) (p = 0.0146). During the first 24 h post-op, the overall incidence of PONV was significantly lower in DEX2 group (10%) than that of Placebo group (32%) (p = 0.0142). There was no significant difference in POV among the three groups. PAED or EA scores among the three groups were similar during recovery time.

conclusionDexmedetomidine (0.5 μg/kg) reduced OCR and PONV without lengthening extubation time or recovery time in pediatric patients undergoing strabismus surgery.

trial registrationThe trial was prospectively registered before patient enrollment at Chinese Clinical Trial Registry (Clinical Trial Number: ChiCTR1800020176, Date: 12/19/2018).

Indexed as

Adrenergic alpha-2 Receptor AgonistsChildDexmedetomidineDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleOculomotor MusclesPostoperative Nausea and VomitingProspective StudiesReflex, OculocardiacStrabismusTreatment OutcomeAdrenergic alpha-2 Receptor AgonistsDexmedetomidineDexmedetomidineEmergence agitationOculocardiac reflexPostoperative nausea and vomitingStrabismus surgery

Identifiers

PMID32138784
PMCPMC7059381
OpenAlexW3012228985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.