SynthesisCritical care (London, England)2020
Elevated central venous pressure is associated with increased mortality and acute kidney injury in critically ill patients: a meta-analysis.
Synthesis in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
VEXUS-REA : Evaluation of Ultrasound Parameters of Venous Congestion in Patients in a Medical Intensive Care Unit
Venous Return Pressure Gradient Predicts Acute Kidney Injury Onset and Progression
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- Pooled it
- Minimally invasive versus conventional continuous-flow left ventricular assist device implantation for heart failure: a meta-analysis.Heart failure reviews · 2022Pooled it
- Mean airway pressure as an independent risk factor for developing acute kidney injury in mechanically ventilated critically ill patients: a multi-center retrospective analysis.Renal failure · 2026Article
- Implementation of a standardized Impella-specific management pathway in cardiogenic shock.Journal of intensive care · 2026Article
- Venous dimension of shock: Integrating arterial inflow and venous back-pressure in hemodynamic assessment.World journal of critical care medicine · 2026Review
- Comparison of Left Ventricular Pressure-Volume Loops With Veno-Arterial Extracorporeal Membrane Oxygenator Support: In Vitro Investigation.Artificial organs · 2026Article
- Pressure-Adjusted Heart Rate Predicts Mortality and Resource Utilization in Cardiogenic Shock: An Analysis of the MIMIC-IV Database.Journal of cardiovascular development and disease · 2026Article
- Development and validation of a proposed rule for estimating central venous pressure from inferior vena cava dynamics: a clinical prediction model study.Journal of anesthesia, analgesia and critical care · 2026Article
- Fluid Tolerance in Acute Kidney Injury: Is Point-of-Care Ultrasound the Future of Hemodynamic Assessment?Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Central Venous Pressure Referencing in the Lateral Position: Comparison With Direct Right Atrial Pressure in Mechanically Ventilated ICU Patients.Acta anaesthesiologica Scandinavica · 2026Observational
- Central Venous Pressure Revisited: Physiology, Pitfalls, Misconceptions, and Modern Clinical Interpretation in Critical Care.Journal of clinical medicine · 2026Review
- VExUS versus CVP for assessing venous congestion: oasis or mirage?Critical care (London, England) · 2026Article
- Role of Central Venous Pressure and Mean Arterial Pressure to Central Venous Pressure Ratio in Assessing Poisoning Severity and Poor Outcomes in Intensive Care Unit-Admitted Acute Aluminum Phosphide-Poisoned Patients.Cardiovascular toxicology · 2026Article
- Impact of central venous pressure trajectories on prognosis in ICU patients with sepsis.Scientific reports · 2026Article
- Lung and Venous Excess Ultrasound Correlation With Intracardiac Pressures Before and After Decongestion in Critically Ill Patients With Acute Decompensated Heart Failure.Critical care explorations · 2026Observational
- The Relationship between Intraoperative Respiratory Variability of the Inferior Vena Cava Diameter on Transesophageal Echocardiography and Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Grafting Surgery: A Prospective Multicenter Cohort Study.Annals of cardiac anaesthesia · 2026Article
- Prognostic value of echocardiography-estimated right atrial pressure beyond the MAGGIC risk score in heart failure patients.Frontiers in cardiovascular medicine · 2026Article
- Atherogenic index of plasma and risk of acute kidney injury in critically ill patients: a multi-cohort study with machine learning and SHAP analysis.Renal failure · 2025Article
- Exploring the Role of Central Venous Pressure in Cardiac Surgery-Associated Acute Kidney Injury: A Comprehensive Scoping Review.Archives of Iranian medicine · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association of central venous pressure (CVP) and mortality and acute kidney injury (AKI) in critically ill adult patients remains unclear. We performed a meta-analysis to determine whether elevated CVP is associated with increased mortality and AKI in critically ill adult patients.
methodsWe searched PubMed and Embase through June 2019 to identify studies that investigated the association between CVP and mortality and/or AKI in critically ill adult patients admitted into the intensive care unit. We calculated the summary odds ratio (OR) and 95% CI using a random-effects model.
resultsFifteen cohort studies with a broad spectrum of critically ill patients (mainly sepsis) were included. On a dichotomous scale, elevated CVP was associated with an increased risk of mortality (3 studies; 969 participants; OR, 1.65; 95% CI, 1.19-2.29) and AKI (2 studies; 689 participants; OR, 2.09; 95% CI, 1.39-3.14). On a continuous scale, higher CVP was associated with greater risk of mortality (5 studies; 7837 participants; OR, 1.10; 95% CI, 1.03-1.17) and AKI (6 studies; 5446 participants; OR, 1.14; 95% CI, 1.06-1.23). Furthermore, per 1 mmHg increase in CVP increased the odds of AKI by 6% (4 studies; 5150 participants; OR, 1.06; 95% CI, 1.01-1.12). Further analyses restricted to patients with sepsis showed consistent results.
conclusionsElevated CVP is associated with an increased risk of mortality and AKI in critically ill adult patients admitted into the intensive care unit.
trial registrationPROSPERO, CRD42019126381.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.