Evidence map›Paper›PMID 32138756›Full record

ReviewJournal of ovarian research2020

Functional activities of beta-glucans in the prevention or treatment of cervical cancer.

Shahla Chaichian, Bahram Moazzami, Fatemeh Sadoughi, Hamed Haddad Kashani, Marsa Zaroudi, Zatollah Asemi

3 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Journal of ovarian research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
8.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04771546 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Evaluation of the Efficacy of an Intravaginal Treatment With Carboxymethyl-β-glucan and Polycarbophil on the Regression of Low-grade Cervical Intraepithelial Lesions

TypeinterventionalSponsorUriach Consumer HealthcareRan2021 to 2023Enrolled200ConditionsHuman Papilloma VirusArmsColpofix
NCT04781023 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Evaluation of the Efficacy of an Intravaginal Treatment With Carboxymethyl-β-glucan and Polycarbophil in the Clearance of High-risk Human Papillomavirus Infection

TypeinterventionalSponsorUriach Consumer HealthcareRan2021 to 2023Enrolled200ConditionsHuman Papilloma VirusArmsColpofix
NCT06199128 completednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Efficacy and Safety of the Local Treatment of Carboxymethyl Beta-glucan and Polycarbophil in Patients With Normal Cytology/ASCUS/LSIL (CIN1) With HPV+ PCR Determination

TypeobservationalSponsorUriach Consumer HealthcareRan2022 to 2023Enrolled533ConditionsHuman Papillomavirus InfectionArmscarboxymethyl β-glucan
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Immune suppressive signaling regulated by latent transforming growth factor beta binding protein 1 promotes metastasis in cervical cancer.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  13. Microbiome research reports · 2022
    Article
  14. Frontiers in oncology · 2022
    Article
  15. Evaluating comparative β-glucan production aptitude ofSaudi journal of biological sciences · 2021
    Article
  16. Review
  17. Review
  18. Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression.Journal of fungi (Basel, Switzerland) · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shahla ChaichianPars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
Bahram MoazzamiPars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh SadoughiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. rahasadoughi@gmail.com.
Hamed Haddad KashaniAnatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Marsa ZaroudiStudent Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran.
Zatollah AsemiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. asemi_r@yahoo.com.
Iran University of Medical Sciences · IRKashan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is the fourth-ranked cancer in the world and is associated with a large number of deaths annually. Chemotherapy and radiotherapy are known as the common therapeutic approaches in the treatment of cervical cancer, but because of their side effects and toxicity, researchers are trying to discovery alternative therapies. Beta-glucans, a group of glucose polymers that are derived from the cell wall of fungi, bacteria, and etc. it has been showed that beta-glucans have some anti-cancer properties which due to their impacts on adaptive and innate immunity. Along to these impacts, these molecules could be used as drug carriers. In this regard, the application of beta-glucans is a promising therapeutic option for the cancer prevention and treatment especially for cervical cancer. Herein, we have summarized the therapeutic potential of beta-glucans alone or as adjuvant therapy in the treatment of cervical cancer. Moreover, we highlighted beta-glucans as drug carriers for preventive and therapeutic purposes.

Indexed as

beta-GlucansCarrier ProteinsClinical Studies as TopicDisease ManagementDisease SusceptibilityDrug Evaluation, PreclinicalFemaleHumansImmunomodulationMolecular Targeted TherapyMyeloid-Derived Suppressor CellsProtein BindingSignal TransductionUterine Cervical Neoplasmsbeta-GlucansCarrier ProteinsAnti-cancerBeta-glucansCervical cancerPreventionSizofiranTreatment

Identifiers

PMID32138756
PMCPMC7057557
OpenAlexW3011260145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.