ArticleRadiation oncology (London, England)2020
Anatomic change over the course of treatment for non-small cell lung cancer patients and its impact on intensity-modulated radiation therapy and passive-scattering proton therapy deliveries.
Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Quantifying the Effect of 4-Dimensional Computed Tomography-Based Deformable Dose Accumulation on Representing Radiation Damage for Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Standard-Fractionated Intensity-Modulated Radiation Therapy.International journal of radiation oncology, biology, physics · 2024Trial
- Dynamic blood dose estimates in radiotherapy and correlations with adverse clinical outcomes in brain, head-and-neck, and lung cancer patients.Journal of applied clinical medical physics · 2026Article
- Key technologies and challenges in online adaptive radiotherapy for lung cancer.Chinese medical journal · 2025Review
- Time series analysis of dosimetric changes in target volumes and organs at risk monitored by cone beam computed tomography during radiotherapy for non-small-cell lung cancer.Physics and imaging in radiation oncology · 2025Article
- Artificial intelligence for response prediction and personalisation in radiation oncology.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Review
- Exploring the Potential of Gold Nanoparticles in Proton Therapy: Mechanisms, Advances, and Clinical Horizons.Pharmaceutics · 2025Review
- Mid-treatment adaptive planning during thoracic radiation using 68 Ventilation-Perfusion Positron emission tomography.Clinical and translational radiation oncology · 2023Article
- Explainability and controllability of patient-specific deep learning with attention-based augmentation for markerless image-guided radiotherapy.Medical physics · 2023Article
- Current Landscape of Therapeutic Resistance in Lung Cancer and Promising Strategies to Overcome Resistance.Cancers · 2022Review
- Locally advanced NSCLC: a plea for sparing the ipsilateral normal lung-prospective, clinical trial with DART-bid (dose-differentiated accelerated radiation therapy, 1.8 Gy twice daily) by VMAT.Radiation oncology (London, England) · 2022Article
- AAPM Task Group Report 290: Respiratory motion management for particle therapy.Medical physics · 2022Article
- Article
- Anthropomorphic lung phantom based validation of in-room proton therapy 4D-CBCT image correction for dose calculation.Zeitschrift fur medizinische Physik · 2022Article
- Dosimetric impact of tumor position displacements between photon and proton stereotactic body radiation therapy for lung cancer.Journal of radiosurgery and SBRT · 2022Article
- Imaging Strategies in Proton Therapy for Thoracic Tumors: A Mini Review.Frontiers in oncology · 2022Review
- Concurrent chemoradiotherapy for stage III non-small-cell lung cancer: recent progress and future perspectives (a narrative review).Translational lung cancer research · 2021Review
- Adaptive Radiation Therapy in the Treatment of Lung Cancer: An Overview of the Current State of the Field.Frontiers in oncology · 2021Review
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Authors and funding
9 authors.
Funding
Abstract
purposeTo quantify tumor anatomic change of non-small cell lung cancer (NSCLC) patients given passive-scattering proton therapy (PSPT) and intensity-modulated radiation therapy (IMRT) through 6-7 weeks of treatment, and analyze the correlation between anatomic change and the need to adopt adaptive radiotherapy (ART). MATERIALS AND
methodsWeekly 4D CT sets of 32 patients (8/8 IMRT with/without ART, 8/8 PSPT with/without ART) acquired during treatment, were registered to the planning CT using an in-house developed deformable registration algorithm. The anatomic change was quantified as the mean variation of the region of interest (ROI) relative to the planning CT by averaging the magnitude of deformation vectors of all voxels within the ROI contour. Mean variations of GTV and CTV were compared between subgroups classified by ART status and treatment modality using the independent t-test. Logistic regression analysis was performed to clarify the effect of anatomic change on the probability of ART adoption.
resultsThere was no significant difference (p = 0.679) for the time-averaged mean CTV variations from the planning CT between IMRT (7.61 ± 2.80 mm) and PSPT (7.21 ± 2.67 mm) patients. However, a significant difference (p = 0.001) was observed between ART (8.93 ± 2.19 mm) and non-ART (5.90 ± 2.33 mm) patients, when treatment modality was not considered. Mean CTV variation from the planning CT in all patients increases significantly (p < 0.001), with a changing rate of 1.77 mm per week. Findings for the GTV change was similar. The logistic regression model correctly predicted 71.9% of cases in ART adoption. The correlation is stronger in the PSPT group with a pseudo R
conclusionThe magnitude of target volume variation over time could be greater than the usual treatment margin. Mean target volume variation from the planning position can be used to identify lung cancer patients that may need ART.
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