Observational studyBMC neurology2020
Incidence and predictive factors of diaphragmatic dysfunction in acute stroke.
Observational study in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of respiratory muscle training on diaphragm function in stroke patients: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Efficacy of diaphragmatic breathing exercise on respiratory, cognitive, and motor function outcomes in patients with stroke: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Effect of unstable surface during loaded-inspiratory task on diaphragm and trunk muscle activity in stroke patients.European journal of applied physiology · 2026Trial
- The relationship between diaphragmatic dysfunction and sleep, emotional state, quality of life, and functional status in patients with chronic ischemic stroke.Turkish journal of physical medicine and rehabilitation · 2026Article
- Correlation between swallowing and diaphragmatic functions in stroke patients with hemiplegia: a cross-sectional observational study.Scientific reports · 2026Observational
- Risk factors postoperative diaphragmatic dysfunction in video-assisted thoracic surgery patients: a dynamic digital radiography study.Journal of thoracic disease · 2026Article
- Electroacupuncture-Induced Phrenic Nerve Stimulation for Poststroke Pneumonia: A Propensity Score Matching Analysis.BioMed research international · 2026Article
- Test-retest reliability of a novel unilateral thoracic expansion measurement using stretchable strain sensors.Journal of physical therapy science · 2025Article
- Using ML techniques to predict extubation outcomes for patients with central nervous system injuries in the Yun-Gui Plateau.Scientific reports · 2025Article
- Padua Days on Muscle and Mobility Medicine, March 25-29, 2025, Hotel Petrarca, Euganean Thermae, Italy: Program and Abstracts.European journal of translational myology · 2025Article
- Diaphragm and sternocleidomastoid muscle activity with increasing inspiratory pressure loads in people after stroke.Scientific reports · 2025Article
- Effects of external diaphragm pacing combined with repetitive peripheral magnetic stimulation of the phrenic nerve on respiratory function in stroke patients.Frontiers in medicine · 2025Article
- Diaphragm dysfunction: how to diagnose and how to treat?Breathe (Sheffield, England) · 2025Review
- Article
- Bi-parametric MRI of the Diaphragm Using Dynamic and Static Images: The Initial Experience.Cureus · 2024Article
- The effects of respiratory muscle training on respiratory function and functional capacity in patients with early stroke: a meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Review
- Volitional inspiration is mediated by two independent output channels in the primary motor cortex.The Journal of comparative neurology · 2023Article
- Ultrasonic Evaluation of Diaphragm in Patients with Systemic Sclerosis.Journal of personalized medicine · 2023Article
- Respiratory muscle ultrasonography evaluation and its clinical application in stroke patients: A review.Frontiers in neuroscience · 2023Review
- Assessment of Diaphragm in Hemiplegic Patients after Stroke with Ultrasound and Its Correlation of Extremity Motor and Balance Function.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most characteristic clinical signs of stroke are motor and/or sensory involvement of one side of the body. Respiratory involvement has also been described, which could be related to diaphragmatic dysfunction contralateral to the brain injury. Our objective is to establish the incidence of diaphragmatic dysfunction in ischaemic stroke and analyse the relationship between this and the main prognostic markers.
methodsA prospective study of 60 patients with supratentorial ischaemic stroke in the first 48 h. Demographic and clinical factors were recorded. A diaphragmatic ultrasound was performed for the diagnosis of diaphragmatic dysfunction by means of the thickening fraction, during normal breathing and after forced inspiration. Diaphragmatic dysfunction was considered as a thickening fraction lower than 20%. The appearance of respiratory symptoms, clinical outcomes and mortality were recorded for 6 months. A bivariate and multivariate statistical analysis was designed to relate the incidence of respiratory involvement with the diagnosis of diaphragmatic dysfunction and with the main clinical determinants.
resultsAn incidence of diaphragmatic dysfunction of 51.7% was observed. 70% (23 cases) of these patients developed symptoms of severe respiratory compromise during follow-up. Independent predictors were diaphragmatic dysfunction in basal respiration (p = 0.026), hemiparesis (p = 0.002) and female sex (p = 0.002). The cut-off point of the thickening fraction with greater sensitivity (75.75%) and specificity (62.9%) was 24% (p = 0.003).
conclusionsThere is a high incidence of diaphragmatic dysfunction in patients with supratentorial ischaemic stroke which can be studied by calculating the thickening fraction on ultrasound. Among these patients we have detected a higher incidence of severe respiratory involvement.
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